550 ME. J. PEIESTLEY ON THE PHYSIOLOGICAL ACTION OF VANADIUM. 
Exp. LXXVX. — June 3, 1875. 
Frog. — Weight 35 grms. 
Dose -5 cub. centim. of the 5 per cent, solution (25 milligrammes 
V 2 0 5 ), injected under skin. 
h. m. 
12 30. Cord divided and brain destroyed. 
3 40. Injection complete. 
In rather more than an hour reflex activity had ceased. 
Exp. LXXVII.— June 3, 1874. 
Note . — This experiment was made to serve as a standard for the preceding. 
Frog. — Weight 25 grms. 
Dose *5 cub. centim. pure water injected subcutaneously. 
li. m. 
12 30. Cord divided and brain destroyed. 
3 35. Experiment commenced. 
Keflex activity diminished very slowly. 
7 0. Fair reflex movements on pinching or irritating the skin with acid. 
Left for the night in a moist chamber. The next day all reflex power 
seemed to be absent. 
It may be noticed that in these experiments, as the parts above the atlanto-occipital 
articulation were destroyed, the cord alone is concerned in the reflex acts, inhibition of 
reflex power by the optic lobe (Setchenow) being no longer possible. 
The Tables based on these experiments, and figured on Plate 45. figs. 1 & 2, show at 
once the action of vanadium upon the reflex function as compared with the effects of 
gradual death in a frog under conditions exactly similar, except that it was not poisoned. 
With regard to the conducting power of the cord for electrical stimuli, these experi- 
ments confirm preceding ones in indicating that vanadium does not affect it at all. 
The following experiments were undertaken in order to examine more minutely the 
effects of vanadium upon the contractility of muscle. 
Exp. LXXVIII.— June 1875. 
Three frogs were taken, two of which were poisoned by the subcutaneous injection of 
about 1 cub. centim. of a 5 per cent, solution of vanadate of soda ( = 50 milligrammes 
v 2 o 5 ). 
When paralysis had completely occurred in one frog, it and the non-poisoned frog 
were decapitated, and the gastrocnemii of each arranged in a Pflugee’s myographion, 
for recording the length of contraction under different loads. The muscles were directly 
