216 
DR. E. KLEIN ON THE SMALLPOX OF SHEEP. 
the peripheral part only being red. One puncture failed and one pock disappeared four 
or five days after its appearance ; the others were excised, thus — 
No. 1 on the 13th December. 
„ 2 „ 14th „ in the morning. 
„ 3 „ 14th „ in the evening. 
„ 4 „ 15th 
„ 5 „ 16th „ 
„ 6 „ 16th „ 
„ 7 „ 21st „ 
Only No. 7 showed commencing pustulation. 
Tlie relation of the temperature of the animal was as follows : — 
Decembei 
• 8 (before inoculation) . 
. 39*3 
55 
9 
. 39 
55 
10 
. 39 
'55 
11 
. 39-1 
„ 
12 
. 39-3 
55 
13 
. 39*5 
55 
14 
. 40-2 
55 
15 
. 41 
16 
. 40-4 
55 
17 
. 40 
„ 
18 
. 39-8 
55 
19 
. 39-2 
55 
20 
From this it appears that before the eruption of the variola; the temperature rose 
only gradually ; whereas it rapidly increased during the eruption and the increase of the 
pocks in size, and it became lower again as soon as they ceased to make any marked 
progress. 
Experiment 2. — A second quantity of lymph from the same source as that used in 
experiment 1 was used in a similar manner. On the evening of January 15th, 1874, 
extremely small quantities of lymph were injected into the true skin of the groin of a 
sheep with the aid of a subcutaneous Pravaz syringe, four punctures being made on the 
right side and three on the left. On the evening of January 19th all the seven punc- 
tures were recognizable as circumscribed red elevations, the centre of which (the punc- 
ture) was marked as a brownish speck. All of these increased in size until January 
24th, and while doing so they changed in the same manner as those in experiment 1 : 
they became pale and depressed in the centre ; whereas the periphery remained very much 
elevated above the general surface, and at the same time much reddened. 
