232 
DE. E. KLEIN ON THE SMALLPOX OE SHEEP. 
now swollen, distinctly granular, and their nucleus in the act of division or already 
divided. The changes of the walls of the blood-vessels, as stated above, are now to be 
traced not only in the blood-vessels of the corium, but also in those of the superficial parts 
of the subcutaneous tissue. Although the oedema and infiltration with lymph-corpuscles 
is chiefly limited to the corium, still it is noticeable that the subcutaneous tissue has in 
some places, especially around larger blood-vessels, become also materially involved in 
the morbid process, the interfascicular spaces being in some places very markedly 
distended, and containing not only a few lymph-corpuscles, but also a finely granular 
material, in which are imbedded peculiar ovoid or spherical sharply outlined structures, 
containing in a clear substance one large or two, three, or four small highly refractive 
bodies. These structures are of different sizes, the smallest being not smaller than the 
nucleus of a connective-tissue corpuscle, the larger ones two or three times as large. 
The connective-tissue corpuscles which line the bundles of the connective tissue are at 
the same time enlarged ; they appear swollen, granular, and their nucleus single or 
divided. 
Comparing the sharply outlined structures found in the interfascicular spaces, as 
mentioned just now, amongst themselves, one cannot help thinking that the highly 
refractive bodies found in their interior are in the state of undergoing proliferation by 
division. 
I will draw the attention of the reader to Plate 32. fig. 12, which shows these rela- 
tions very accurately. The question now arises, What are these sharply outlined struc- 
tures with the highly refractive bodies in their interior % 
That these bodies are free nuclei must he excluded at once, — first, free nuclei not 
being observable anywhere else in the tissue ; and, secondly, the nuclei of connective- 
tissue corpuscles and of lymph-corpuscles being altogether different. The issue rests 
only between their being lymph-corpuscles (extravasated) or something not belonging 
to the skin at all ; I mean, a fungus. In case they should be lymph-corpuscles, the 
transparent sharp-outlined matrix would represent the swollen cell-substance, and the 
highly refractive bodies in their interior would correspond to the shrunken coagulated 
nuclei. It certainly cannot be denied that pus- or lymph-corpuscles, when treated with 
dilute acids (i. e. chromic acid, acetic acid), show appearances similar to those just 
mentioned ; but in the present instance, although the preparation, in question had 
been hardened in chromic acid, no such appearance was to be found either in the lymph- 
corpuscles situated in the corium or in the veins and lymphatic vessels of the sub- 
cutaneous tissue. In these parts the lymph-corpuscles appeared as they do in general 
in hardened preparations, viz. as spherical more or less transparent or finely granular 
cells, containing one relatively large nucleus, and seldom two or three small spherical 
nuclei which are readily stained with carmine. The structures in question not only 
differ from lymph-corpuscles in shape, but they also show a great difference in then- 
contents — the contents of the former being highly refractive bodies in the state of 
division, which are not stained with carmine at all. 
From all this it is probable that they are not lymph-corpuscles ; and therefore it is 
