N. 0. ANAOiRDIAOEiE. 
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one and a half drachm to two drachms and a half. In some 
very severe cases, when the patients were very strong and 
robust, the dose was'increased to three drachms ; but the average 
dose is two drachms, which is the one I have most frequently 
employed in my practice. As soon as the patients are much 
relieved and able to walk about to some extent without 
assistance, I generally omit the drug and complete the cure with 
milder or less active medicines, such as salicylate of soda, 
colchicum, alkalines, and with stimulant embrocations. 
“ In chronic and muscular forms of rheumatism, however, 
the marking-nut is not half as useful as it is in its acute variety, 
and I am therefore unable to speak much in its favour in the 
treatment of the former diseases. 
“ Marking-nut is also a good therapeutic agent in asthma, but 
the relief it affords in so small doses as those mentioned in some 
books, is very slight. To secure its best effects in this disease 
it should be used repeatedly and in doses similar to those 
I generally employ in acute rheumatism. Gout is so rare 
among the Natives of this country that I never had an 
opportunity of using this drug in any well-marked case of that 
disease during the last two years ; but from its great influence 
over acute rheumatism ; I am almost sure that it will also 
produce good results in the acute form of the former. 
“ There is a notion among the Natives of Southern India that 
the internal use of the marking-nut is apt to produce sore mouth 
or ptyalism, but I have never met with a single instance of 
of these bad effects, though I have administered the drug in 
many cases and in so large and repeated doses as those explained 
above. 
“ During the employment of the marking-nut, either external- 
ly or internally, the least appearance of a rash or redness of the 
the skin, or an itchy or uneasy sensation in any part of the 
body, should be considered as a sign of the bad effects of the 
drug, and it should, therefore, be stopped immediately. Spiritus 
ammoniae aromaticus is to be freely administered, with some 
demulcent drinks, such as infusum lini ; and some oil, olive or 
cocoanut, should be constantly smeared over the affected part 
