N. 0, KUFACE.E. 
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above. It, therefore, demands an especial notice of the medi- 
cal profession. 
“ Six drachms of the tincture or twelve ounces of the decocr. 
tion of T. aculeata are equal to one bottle of Warburg’s 
tincture ; and if either of them is used in two doses during 
the presence of simple continued fever or a paroxysm of . ague, 
it produces the same good effect*as the latter drug (Warburg’s 
tincture), namely, a copious perspiration and relief of the 
febrile condition ; and, again, if the tincture or decoction is 
repeated in the same dose during the interval of ague, every 
fourth or fifth hour, for two or three days, it prevents the 
return of paroxysm as successfully as very large doses of 
quinine. To render the cure more perfect and complete, the 
tincture or decoction should be continued in smaller doses for 
four of five days more. The beneficial influence of the tincture 
or decoction of T. aculeata in remittent fever is precisely the 
same, and the only difference is that it sometimes relieves the 
exacerbation and checks its return at once; and at others, it 
first converts the remittent into intermittent fever and then 
cures the latter in the same way as explained above. Out of 
the many severe and very obstinate cases of malarious, jungle, 
and other fevers, which yielded to this drug, there were several 
in which quinine with arsenic was first tried and failed. As. the 
dose of the tincture of T. aculeata is much smaller than that of 
its decoction, and as it can also be prepared and kept always ready 
for use, it is preferable to the latter; but there is no difference 
whatever between the medical properties of both preparations. 
“ The root-bark of T. aculeata is not only much cheaper 
than quinine and Warburg’s, tincture, but is also one of the 
cheapest drugs in Southern India, its price being only about 
2 annas per pound. In addition to this, its advantages over 
quinine are that it, unlike the latter, can be freely and success- 
fully administered in the absence as well as in the presence 
of fever ; and that, however long and frequently it may be em- 
ployed, it never produces ringing in the ears, deafness and 
some other disagreeable symptoms which are so commonly 
observed in the use of quinine. 
