3io Wager.— On the Structure and 
other parts of the mycelium the formation of sporangia 
ceases. 
In 1892 I gave a description of the structure of the nuclei 
of C. Candidas , and pointed out the multinucleate nature of 
the oogonium and antheridium. Like Dangeard I was, how- 
ever, unable to observe fertilization or the fate of the nuclei 
in the oosphere, and agreed with him that Fisch had mistaken 
the central oil-globule for a nucleus. Since then I have been 
able to disprove this, as will be seen later. 
Peglion (’93) in a paper on the hypertrophy of the tissues 
produced by C. Candidas on Raphanas R aphanistmm, points 
out that large accumulations of starch are produced where 
the conidia pustules are formed. The epidermal cells and the 
cortical parenchyma are increased in size, the former especially 
tangentially, and the vascular bundles are modified. 
Macallum (’95), in his paper on the distribution of assimilated 
iron in animal and vegetable cells, shows that a substance in 
which iron is firmly held appears to be a constant constituent 
of the nucleus and of the cytoplasm of non-nucleated cells 
and those possessed of apparently rudimentary nuclei. He 
says that in Cystopus Candidas the whole of the protoplasm 
in the mycelium and gonidia, except the mature gonidia, is 
chromophilous, that is, contains chromatin. The nuclei in the 
mature gonidia are of the more regular form, but in the myce- 
lium are chiefly, if not wholly, small masses of chromatin 
substance, like those forming the ‘nucleoli’ in the abjointing 
gonidia. Mitotic phases were not seen. 
The disposition of the assimilated iron corresponds closely 
with the distribution of the chromophilous substance. The 
small masses of chromatin and the nucleoli gave abundant 
evidence of its presence, the remaining portion of the nucleus 
in the case of the latter containing very little, relatively less 
than the cytoplasm. 
In the subsequent development of the abjointed gonidia, 
the nuclei appear to take up from the protoplasm all, or nearly 
all, the substance containing' iron, and with this the character 
of the nuclei seems to change. The nucleoli first of all are 
