29 e ANNÉE 
NOVEMBRE 1915 
N° 11 
ANNALES 
DE 
L’INSTITUT PASTEUR 
✓ 
Mémoire publié à 1 occasion du jubilé de E. METGHNIKOFF. 
REMARKS ON THE NATURE AND SIGNIFICANCE 
OF THE SO-CALLED 
“ INFECTIVE GRANULES ” OF PROTOZOA 
by E. A. MINCHIN (1). 
Du ring the past few years several investigators hâve observed 
the extrusion of minute corpuscles from the hodies of various 
Protozoa parasitic in the blood of Vertebrates. The first obser- 
vation of this kind appears to hâve been made by Major W. B, 
Frv in 1911, who communicated bis results lo the Royal Society 
in June 1911. He regarded these socalled granules as true de- 
velopmental stages of the parasite which, after extrusion from 
the hody of the Irypanosome, were capable of developing into 
the a> luit form again. Similar observations were made on the 
spirochætes of fowls by Dr. Andrew Baifour, in whose labora- 
tory at Khartoum the observation of Fry were made, and who 
proposed for these bodies the lerm « infective granules ». 
At the time when the discoveries of Fry and Baifour were 
published, I was engaged in writing my text-book on the Pro- 
(1) E. A. Minchin, professeur de protozoologie à l’Université de Londres, 
membre de la Société Royale, a succombé en octobre dernier à une longue 
maladie. La rédaction des Annales s’associe aux regrets causés par la mort 
prématurée de cet éminent zoologiste. 
30 
