( 781 ) 
Physiology. — “Contributions to the study of serum-anaphylaxis” 
(From the “Institut fur Infektionskrankheiten” at Berlin). By 
Dr. J. Gr. Sleeswijk. (Communicated by Prof. C. H. H. Spronok). 
(4* *th communication.) 
(Communicated in the meeting of March 26, 1910). 
During the first months of last year I had an opportunity, in three 
communications 1 ), to make the results of my investigations about 
serumanaphylaxis known to the Academy. Since that time the lite¬ 
rature about this subject has not inconsiderably increased. It is not 
my intention at all here to go in for a discussion of this. Only let 
it be allowed to me (and I even consider myself obliged to do this 
before the Academy) to treat here in a few words of these publica¬ 
tions, in which my own investigations either directly or indirectly 
were discussed, and to add the results of a number of further ex¬ 
periments. May it be presupposed that in general the facts commu¬ 
nicated by me must be acknowledged as correct. 
Principally we have to pay attention to three points: 
1 st . the part of the red corpuscles of the guinea-pig with respect 
to horse-serum in the phenomenon of Th. Smith, 2 nd . the problem 
of the alexine-fixation and of the haemolysis in the anaphylactic 
shock, and 3 rd the application of the specific hypersensibility for 
proteins in medicina forensis. 
Last year I explained why I was of opinion that the sensitizing 
principle of the first injection and the toxic substance of the second 
administering of serum must be considered identical and that only 
quantitative differences are met with here. In the meantime Besredka ! ) 
has changed his mind and taken this standpoint. Now the logical 
consequence of my observation that horse-serum by treatment with 
the blood of a guinea-pig can be deprived of its poisonousness for 
animals made sensitive, was therefore that with this at the same 
time the sensitizing substance is fixed. Levaditi and Raychman, who 
could also really prove what I mentioned last, do not refrain, therefore, 
in this connection, from referring to my communication. *) Also 
Salus corroborated my observation concerning the depoisoning action 
of the red corpuscles on horse-serum. 4 ) 
The problem of the complement fixation has of late attracted 
attention to a high degree. I remind of my first communication in 
which I said already, “that a sensitized guinea-pig, which reacts 
*) These Proceedings: January, February, and March 1909. 
®) Ann. de l’lnst. Pasteur, Oct. 1909. 
s ) G. R. Soc. de Biol. T. 67, 1909, p. 1078. 
*) Wiener Klin. Woch. 1909, no. 48. 
