PHYSIOLOGICAL ACTION, AND ANTAGONISM. 
211 
Rabbits, Tabulation of Results. 
Fatal. 
10 c.c. or less.* 
Fatal in— 
20 c.c. or above 10 c.c. 
Fatal in— 
10 c.c. Dimethyl-ammon. chloride. 
10 c.c. Trimethyl-ammon. chloride 
10 c.c. Biethyl-ammon. iodide. . . 
10 c.c. Tetraethyl-ammon. iodide . 
10 c.c. Tetramethyl-ammon. iodide 
5 c.c. Tetramethyl-ammon. iodide. 
5 c.c. Tetraethyl-ammon. iodide . 
Several hours. 
A few hours. 
2 h 30 m . 
2 h 30 m . 
2 h 4 m . 
5 m 
30 m . 
20 c.c. Triethyl-ammon. sulphate . 
20 c.c. Trimethyl-ammon.sulphate 
20 c.c. Ethyl-ammon. iodide 
18 c.c. Amyl-ammon. iodide. 
17 m . 
3 h 15 s . 
Several hours. 
3 h . 
Not Fatal. 
With Maximal Dose recovered from— 
2 c.c. 
10 c.c. and more than 2 c.c. 
20 c.c. and more than 10 c.c. 
Methyl-ammon. sulphate. 
7 c.c. Trimethyl-ammon. sulphate. 
10 c.c. Ethyl-ammon. iodide. 
10 c.c. Triethyl-ammon. iodide. 
10 c.c. Diethyl-ammon. chloride. 
10 c.c. Triethyl-ammon. chloride. 
10 c.c. Amyl-ammon. iodide. 
10 c.c. Diethyl-ammon. iodide. 
16 c.c. Triethyl-ammon. iodide. 
20 c.c. Amyl-ammon. sulphate. 
20 c.c. Ethyl-ammon. sulphate. 
20 c.c. Diethyl-ammon. sulphate. 
20 c.c. Dimethyl-arnmon. sulphate. 
19 c.c. Methyl-ammon. sulphate. 
20 c.c. Methyl-ammon. iodide. 
20 c.c. Dimethyl-ammon. iodide. 
17 c.c. Trimethyl-ammon. iodide. 
17 c.c. Diethyl-ammon. chloride. 
The order of fatality considering— 
I. The salt. 
1. Iodides. 
2. Chlorides. 
3. Sulphates. 
II. The ammonia compound. 
1. The tetraethyls and tetramethyls. 
2. The triethyls and trimethyls. 
3. The diethyls and dimethyls. 
4. The amyls, ethyls, and methyls. 
appears to be :— 
The former (I.) is of very secondary importance to the latter, and the difference 
between the iodides, and chlorides, and sulphates is magnified by the fact that in the 
case of the iodides alone were the tetra compounds employed. 
In regard to rapidity of action, we find (1) tetramethyl-ammonium-iodide (5 c.c. = ‘5 gr.) 
fatal in 5 m ; (2) triethyl-ammonium sulphate (20 c.c.) in 17 m , and tetraethyl-ammonium- 
iodide (5 c.c.) in 30 m . No symptom of pain occurred in any case after the injection, 
nor of physical change in animal. There appeared occasionally a slight loss of co¬ 
ordination, but this may have been, in some cases, due to paralysis. The pupil was 
markedly affected in the case of trimethyl-ammonium chloride and tetramethyl- 
ammonium-iodide. 
* Each c.c. is equal to ‘1 grm. of the substance named. 
2 E 2 
