242 
DRS. T. L. BRUNTON AND J. T. CASH ON CHEMICAL CONSTITUTION, 
Fig. 25. 
Fig. 26. 
Fig. 27. 
Fig. 28. 
Fig. 29. 
Fig. 30. 
Fig. 31. 
c. Ditto. Application of barium solution continued. Kept for 15 m , cooled 
to 8°'5 C. 
d. Ditto. Heat to 18° C. Reappearance of veratria-like curve. 
e. Ditto. Heat to 20° C. 
f Ditto. Heat to 30° C. The veratria-like curve disappears. 
g. Ditto. Cool to 14° C. There is no return to the veratria-like curve. A 
simple prolonged contraction persists. 
Action of soda on contracting muscle. Solution of 1-2000 admitted at X. 
Stimulation every 2 s . 
a. Action of soda, 1-4000, on contracting curarised muscle. Solution 
admitted at X. 
b. Same muscle after exposure to lactic acid, 1-4000, for 40 m . Stimulation 
every 2 s , direct. 
a. Action of soda, 1-5000, on contracting curarised muscle. Solution 
admitted at X. 
b. Lactic acid, 1-5000, has acted l m on muscle. 
c. Ditto, has acted 5 ra on muscle. Stimulation every 2 s , direct. 
a. Normal gastrocnemius. One opening and one closing stimulation every 4 s . 
b. After G0 m circulation of lactic acid through aorta, 1-8000, stimulation 
causes fibrillation and shortening of muScle. 
c. After 30 m circulation of soda, 1-6000, the strength of contraction, which 
had been diminished under acid, is restored ; fibrillation has ceased. 
a. Normal gastrocnemius. One opening and one closing stimulation every 4 s . 
b. Taken after circulation for 10 ra of 1-20,000 alkaline solution. 
c. Taken after circulation for 30™ of 1 -10,000 acid solution. 
Tracing from gastrocnemius of Cat. One opening and one closing stimulation 
every 4 s . The solution, heated to 38° C., was circulated under pressure 
through the femoral artery, and allowed to escape by the femoral vein. 
The rest of the limb, with the exception of the sciatic nerve, which was 
exposed for stimulation, was ligatured. A weight of 40 grms. was 
applied 2 m before each tracing was taken. Abscisse constant. 
a. Normal contractions. 
b. Alkali, 1-20,000, has circulated 10 m . 
c. Acid, 1-10,000, has circulated 60 m . 
d. Alkali, as before, 20 m . 
e. Ditto, 60 m . Flow from venous canula very slow and weak. 
Action of alkali and acid upon resting muscle (curarised). At the first five 
points indicated by X, soda solution, 1-3000, is supplied to muscle in 
cylinder. At the last six points indicated by a X, lactic acid, 1-1000, 
is supplied. The action of the soda was for 47*5 ,n ; that of the acid for 
42 m . Change of alkali to acid, or vice versd, in all cases shown by 
double-headed arrow. 
