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PROFESSORS D. FERRIER AND G. F. YEO ON THE EFFECTS OF 
On the fifth day the animal passed into a state of coma, in which condition it died. 
Post-mortem examination .— On removal of the dressings pus was found exuding 
from the edges of the wound. The antiseptic arrangements had failed by reason of 
the difficulty of protecting the anterior extremity of the incision. 
The seat of lesion in both frontal regions was covered by a layer of pus. There was 
no adhesion of the dura mater, except slightly at the posterior margins of the lesions, 
but there was general hyper-vascularity of the pia mater. There was however no 
effusion at the base, or sign of suppuration except in the frontal regions as before 
described. 
On removal of the brain the anterior extremities of the frontal lobes with the 
olfactory bulbs and tracts, and the orbital lobules were found to be quite normal; 
free from signs of inflammation. All the cranial nerves were intact. 
The convex aspect of each frontal lobe was the seat of an oval depression, caused 
by loss of substance and suppuration, of almost precisely equal extent, but not quite 
symmetrical as to position. 
On the left the lesion occupied the whole of the middle frontal convolution from 
the precentral sulcus to the orbital margin, and invaded the middle of the superior 
frontal convolution up to within ^th of an inch of the longitudinal fissure, leaving a 
triangular portion of the base, and,a corresponding portion of the anterior extremity 
uninjured. The middle portion of the inferior frontal convolution was also involved 
in the lesion, while the posterior and the anterior extremities were uninjured. 
On the right side the margin of the oval shaped lesion extended slightly farther 
back into the base of the superior and middle frontal convolutions than on the right, 
but did not come so close to the longitudinal fissure. A triangular portion—the base 
posteriorly—of the superior frontal convolution along the margin of the longitudinal 
fissure was intact. The narrowest portion of this measured inch across. 
The inferior frontal convolution was represented only by a portion of the base, 
and a small apex anteriorly. 
Remarks .—This case was unsuccessful in a surgical point of view, the antiseptic 
arrangements having been imperfectly carried out, hence suppuration and complication 
of the phenomena ascribable to the experimental lesions. 
But there was plainly in the first instance, before such complications occurred, as 
the result of destructive lesions of the regions,—electrical irritation of which causes 
movements of the head and eyes to the opposite side—[centre 12 (Ferries,)] —abolition 
or great impairment of the lateral movement of the head and eyes, and instability of 
the head and neck, all other movements being unimpaired. There was no defect in 
tactile sensibility in the head and neck or other part of the body, or in the faculties 
of special sense. The mental aspect of the lesions w T as general apathy as regards 
surroundings, varied by aimless restlessness. 
Notwithstanding' the further extension of the original lesions by inflammation and 
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