318 
THE EIGHTH REMITTANCE OE BARK FROM INDIA. 
Alkaloids dried at the temperature of the air ... . 
Of which soluble in ether, quinine, etc. . . . 8"70 ) 
„ „ insoluble in ether, cinchonine, etc. . T90 ) 
10-60 
For the third or present harvest of renewed bark— 
Alkaloids dried at the temperature of the air 
Of which soluble in ether, quinine, etc. . . 
„ „ insoluble in ether, cinchonine, etc. 
. . . 11-20 
9-40 \ 
1-80 ] 
It will be seen that the proportion of alkaloid has increased, but this would be no 
guide to the commercial value, which is almost entirely regulated by the proportion 
capable of being converted into crystallized salts. More valuable commercial informa¬ 
tion, consequently, will be gained from the following corrected analysis:— 
Quinine (as sulphate).5'33 
„ uncrystallizable .... 2-00 (?) 
- 7-33 
Cinchonidine.1*14 
Cinchonicine.053 
9-00 
I have attached a (?) to the weight of the proportion of uncrystallizable quinine, 
which it was impossible to ascertain exactly from so small a quantity of bark. More¬ 
over, from its great implication with resinous colouring matter, I am led to doubt the 
possibility of obtaining any part of it as crystallized sulphate of quinine on a large scale. 
This uncrystallizable portion is, therefore, unimportant and not to be reckoned, from a 
commercial point of view, as possessing any value to the purchaser of such bark for ma¬ 
nufacturing purposes.* 
The analysis of No. 2, “ Boot bark from a tree of C. succirubra seven years old,” pre¬ 
sented much interest, as bearing on the question as to which of several modes of culti¬ 
vation is to be preferred, since it has recently been proposed to cultivate the plant, like 
madder, solely for the roots. 
I consequently have forwarded about half the sample of No. 2 and also No. 3 (of 
which a very small quantity was sent from India) to Dr. de Vrij, as it was desirable thus 
to arrive at a consentaneous agreement on the value of the root bark, which I have 
always regarded unfavourably, judging from the root bark of C. Calisaya , var. Jose- 
phiana, occasionally found in the market. 
The analysis was troublesome, although the hydrated alkaloids were obtained in a 
state more free than often from colouring matter. The weight of the precipitated alka¬ 
loids appeared to be 12 - 75 per cent., but this hopeful amount did not yield proportionate 
results, probably from an amount of wax and resin being carried down with the alka¬ 
loids. I obtained with difficulty a small crystallization of sulphate of quinine, and the 
remaining liquor, when precipitated, dissolved in ether, and the solution left to concen¬ 
trate by evaporation, furnished crystals of cinchonidine adhering to the sides of the 
vessel, and at last uncrystallizable quinine containing a portion of quinidine. 
The remarkable feature was the large production of fine cinchonine, quite insoluble 
in ether, yielding good crystals from spirit of wine, and these, when formed into 
sulphate, giving the very characteristic salt. In all this the root bark is decidedly 
superior; but, it will be observed, it is cinchonine , and not quinine , that (at all events in 
this species) is the product of this root bark. I give the total as follows :— 
* The weight of the crystallizable, and consequently more valuable portion, was ascertained 
by the following process:—The 6T5 per cent, (as above) having been precipitated, the preci¬ 
pitate was dissolved in ether, separating thus the cinchonidine and the quinine, then dried at 
212° F. It must be understood that quinine thus obtained from the C. succirubra, although 
sufficiently pure to pass the tests required in commerce, retains some cinchonidine, which can 
be separated by solution in acid and subsequent treatment with iodide of potassium. 
