304 
TRANSACTIONS OF THE PHARMACEUTICAL SOCIETY. 
tincture) as a remedy m all fevers, including remittent and typhoid, lias been 
highly favourable. In dyspepsia too, and in diarrhoea, it is most serviceable 
In disorders of the former class, I have combined arsenic with the barberry with 
most successful results, and in many instances have preferred the Tincture of 
Barberry to quinine, as it does not produce any of those disagreeable sensations 
which aie caused by the latter. Lt acts very much in the same way as War¬ 
burgs Fever Drops. Ihe dose in intermittent fevers is 5 iii with mv to mviii 
of Liquor potasses arsemtis The second dose may be given half an hour after 
the first and then one drachm doses without the arsenical solution everv two 
lours till two or three doses are taken. The patient must retire to bed and be 
well covered over as soon as the first rigor or chill is felt; and should the tongue 
of tho tWh- the an GmetlC Sh0llld be S lven P^vious to the administration 
menced 11 ’ ^ && S °° n ™ vomitatlou has ceased the tincture may be com- 
I he directions for taking Warburg’s Drops are in fact very applicable to this 
li t^7i ? C U1 ' e ' and 1 am much inclined to believe that the basis of this cele¬ 
brated febri luge is composed of Tincture of barberry, though it is commonly 
Tree 0 fAW/° ^ 80 }? U ° n f bibi f ine > a “ ^kaloid obtained from the Greenheart 
Rodisei), which grows in the West Indies. Dr. Boyle says 
same^timeS ^ ^ Warbur g’ s Fever Drops, but at the 
no-trnn?oft n f \ ^ ere has Smce a PP eared rea son to suppose that this secret. 
oTrurn often, if not always, contains quinine. In a formula for making War- 
burg s Drops, published I believe in the Lancet, the ingredients are stated to be 
QuiS^d g Ke?S a ed ,0 SpW?’ ^ R °° tS ’ Cam P hor ’ Saffron > 
In the year 1858,1 procured berberine in a crystalline form from the barberry 
ivlnch I received from Nynee Tal, and while Medical Officer at Ootacamand I 
gherly Hite® ^ 7 ° f the alkaloid from tlie Ba * procured on the Neil- 
heandnTS'" the W™? ° f Anncds alr eady quoted, states that both 
berhlnffie mid T T ara ; ProW ,°f Chemistry at Calcutta, failed iu extracting 
„„ e j lne > ' 1 ali »ost agree with him in believing the failure to be of little 
r no importance, as the tincture is so efficacious. 
arberr y bark is now being used by many of the coffee-planters in Wynaad 
where fever amongst the coolies is of very frequent occurrence. 
+b^iL D u NI i EL II ^ N 5 I [ :RYSaid tlj e author of the paper appeared not to be aware 
lo It. I 6 ? 7 ad b , ee i l nade the Sllb J ect of cheraical investigation, and that 
some important papers had been published on the subject. 
• Aw Attf *eld said lie had examined the specimens accompanying the paper 
L r j np ead V 1 gave a 1 tbe nbemical and microscopical reactions of pure ber- 
small nnnn?V IL f P ° SSe f! d B 1 B l llar . character s. but apparently was mixed with a 
lSs « A ? f , a . sub ® 1banc 1 e having a darker yellow colour than berberine, and 
wfrdpd wL m m ! COh °] tban that alkaloid ‘ The qnantity of material for- 
^rbertl?nX the body mixed with the 
decrvtJ It, A?* U ’ 1 ^ 0uld . P robabl y be found to differ from berberine in 
reactions of beAerine. ’ “ preSeDCe See ” ed si “ ply t0 inteDsify the usual 
his P nauTbl Bentley re gretted that the author had not added to the value of 
hum!)i sv<!tPm lV1 cf S ° me “ otlce tbe physiological effects of berberine on the 
needed Is -real experiments upon this point were much 
hcL n o l b i p , C 1 ertaint y “°w prevailed. It was very remarkable to find in 
covered "^PrniW; be £ ng ^ a g ^ different natural orders berberine had been dis- 
covered. 1 rofessor Bentley had recently noticed, in more than one instance. 
