CHLORODYNE. 417 
usually contains from 30 to 40 per cent, of water, ancl I think it is best to 
employ it in this moist condition. 
Soap may be quite as readily made from olive oil by the foregoing method, 
but I think the use of almond oil will be found to present several important ad¬ 
vantages. Although the latter is the dearer material, it does not sensibly affect 
the cost of the liniment, because the soap is to a greater extent soluble ; conse¬ 
quently, the quantity of product is increased, and the proportion of spirit re¬ 
tained in the undissolved matter is saved. 
CHLORODYNE. 
BY EDWARD SMITH, F.C.S. 
Judging from the papers that have recently appeared in the ‘ Pharmaceutical 
Journal,’ it would seem that there still exist great doubts as to the actual com¬ 
position of this popular remedy. 
There have been published two formula? for the preparation of chlorodyne,— 
one known as Dr. Ogden’s, and quoted by Royle in his 4 Materia Medica,’ the 
other to be found in Squire’s 4 Companion,’ and two more distinct and divergent 
formulae can hardly be conceived. It may be worth while, perhaps, to put them 
side by side. 
Dr. Ogden’s (Royle). 
P> JEther. Chlor. 5 ] 
Chloroform jvj 
Tinct. Capsici 5 SS 
01. Menth. Pip. gtt. ij 
Morph. Mur. gr. viij 
Acid. Perchlor. gtt. xx 
Tinct. Cannab. Ind. 5 j 
Theriacse 5 j 
Acid. Hydrocy. Scheele inxij. 
Squire’s (Companion). 
p, Chloroform ^iv 
JEther 
Sp. V. Rect. ^iv 
Theriacse £iv 
Ext. Glycyrrh. giiss 
Morph. Mur. gr. viij 
01. Menth. Pip. irtxvj 
Syrupi gxviiss 
Acid. Hydrocy. dil. ^ij. 
Dr. Ogden, I believe, published his formula as resulting from analysis, and 
Squire says his formula has been represented to him as the true one ; it is plain, 
however, either that Dr. Ogden’s analysis is worthless, or that Squire’s informa¬ 
tion is derived from unreliable sources. Dr. Ogden gives the amount of morphia 
as eight grains in about nine drachms, Squire gives it as eight grains in about 
thirty-five ounces! 1 The proportion of chloroform, too, differs enormously. In 
the first it amounts to about two-thirds, in the latter to about one-eighth. Dr. 
Ogden says nothing of ext. glycyrrh., syrup, sp. v. rect., or ether, and on the 
other hand, Squire omits all mention of acid, perchlor., tinct. cannabis, or 
capsicum. 
I have not met with the particulars of Dr. Ogden’s so-called analysis, and 
in truth, I am very much inclined to doubt if any chemical analysis has been 
attempted, as the formula bears the impress of improbability on the face of it, 
i. e., supposing that Collis Browne’s chlorodyne be intended ; for instance, the 
dose of the latter as marked on the label is from ten to thirty drops, now this 
would contain, if Dr. Ogden is right, from seven to twenty drops of chloroform, 
a dose which very few practitioners would care to venture upon, particularly 
as it is to be repeated at certain intervals, and in combination with from a sixth 
to half a grain of morphia per dose. I rather suspect that Dr. Ogden’s analysis 
has had more of a physical character attached to it, the organs of taste and 
smell having perhaps greatly assisted the supplementary chemical tests. 
