July 1,1871.] 
THE PHARMACEUTICAL JOURNAL AND TRANSACTIONS. 
3 
5. C. Calisaya from Java. 
Bark gold in April, 1870, at Amsterdam, un¬ 
der the name of— 
“ Java koningskina, No. 1.” 
Total amount of alkaloids, 3 21 per cent. Mi = 
96°'3^. 
The alkaloids consisted of amorphous alkaloid, qui- 
nidine, cinchonine and a trace of quinine. 
(5. G. Calisaya hybrida from Java (C. HassTcar- 
liana, Miq.). 
Bark sold in April, 1870, at Amsterdam, un¬ 
der the name of— 
“Java koningskina, Nos. 2 and 3.” 
Total amount of alkaloids 3'12 5 per cent. [a]j = 
50°'2<x. 
The alkaloids consisted of quinine, quinidine, cin¬ 
chonine, cinclionidine and amorphous alkaloid. 
7. C. Calisaya from Java. 
Bark sold in April, 1870, at Amsterdam, un¬ 
der the name of— 
“Java koningskina, No. 4.” 
Total amount of alkaloids 2'47 per cent. [a]j = 20°^. 
8. C. Pahudiana. 
Bark sold in April, 1870, at Amsterdam un¬ 
der the name of— 
“ Bruine Javakina.” * 
Total amount of alkaloids 1 per cent. [«]j = 138°*c. 
The alkaloids consisted of quinine, cinclionidine and 
amorphous alkaloid, whilst the presence of cinchonine 
was dubious. 
9. C. Calisaya from Bolivia. 
Eastern Bolivian bark. 
Total amount of alkaloids 4 per cent, [a] j = 138°^. 
Notwithstanding the defects still adhering to the 
method, I feel certain that it will prove to be an 
important element in the examination and classifica¬ 
tion of the Cinchona harks. 
The Hague, 20 tli April, 1871. 
PEPSIN. 
BY G. A. ZWICK. 
So much has been said and written about tliis re¬ 
medy, that the subject would seem nearly exhausted. 
I desire, therefore, only to communicate the result of 
a few experiments just completed; these, with the 
investigations of others, may perhaps lead to the 
adoption of a formula for a preparation of this article 
in the next edition of the U. S. Pharmacopoeia. 
1st. A fresh stomach of a pig was emptied and the 
slimy mucous substance scraped off, spread upon a 
glass plate and dried. 
2nd. The mucous membrane (scraped off as above) 
was dissected from the body of the stomach, cut up 
into moderately fine pieces. This weighed 8 oz.; it 
was digested with 3viij pure glycerine (acidulated with 
5ij muriatic acid) for twelve hours, expressed, and 
more glycerine added till ^viij were again obtained. 
This fluid was set aside and separated after a few 
da} r s ; the clear was poured off and filtered, warming 
it a little to facilitate filtration. 
3rd. Another pig’s stomach was cleanly washed 
* The barks mentioned under 5, 6, 7 and 8 are the first 
products from the Cinchona plantations in Java brought into 
the market for sale. 
and wiped, macerated with water (acidulated with 
hydrochloric acid) for twelve hours, this water 
poured off and more added, washing and rubbing 
the membrane well. All these washings and the 
first infusion of twelve hours, making 24 ounces, 
were filtered, precipitated with acetate of lead, and 
treated with sulphuretted hydrogen, being the pro¬ 
cess mentioned in the U. S. Dispensatory, but the 
liquid pepsin was evaporated to ^viij only, not to 
dryness. 
To compare these preparations they were tried 
with coagulated albumen. 
No. 1. Six-tenths (ff of a grain of the dry mucus 
dissolved 12 grains albumen. 
No. 2. One fluid drachm of the glycerine prepara¬ 
tion dissolved 12 grains of albumen. 
No. 3. Five fluid drachms (3v) of the watery so¬ 
lution dissolved 12 grains of albumen. 
The above result, however, does not represent the 
utmost solving power, excepting of No. 1. Nos. 2 
and 3 suffered losses of pepsin. No. 2 lost pepsin 
on account of being digested and warmed while still 
in contact with the mucous membrane, and I am 
sure considerable pepsin was lost, as the mass be¬ 
came quite soft and pulpy. The process should be 
carried on cold. No. 3 lost some of the precipitate 
during washing. This process is not practicable 
in warm weather, as the liquors decompose rapidly. 
Summing up my experience, I should take No. 2 
as the process furnishing the most permanent prepa¬ 
ration, being agreeable both to the eye and the palate 
of the patient. It has a bright, clear straw-colour, 
an agreeable bland taste and could be made double 
the above strength. It is not subject to the changes 
and other objections of the powders, is ready when it 
passes out of the hands of the apothecary, without 
further mixing, and not objectionable in taste to the 
most fastidious.— Amer. Journ. of Pharmacy. 
SYRUPUS CALCIS LACTO-PHOSPHATIS. 
BY WILLIAM NEERGAABD. 
In the Archives Cenerales de Medecine for De¬ 
cember, 1869, and for January and February, 1870, 
Dr. L. Dusart recommends the use of a new prepa¬ 
ration, which he terms the lacto-pliospliate of lime, 
in which the lime salt is dissolved in free lactic acid. 
Dr. B. W. M‘Cready, of Philadelphia, requested 
me to prepare a syrup containing that compound, 
and I adopted the following formula:— 
Concentrated Lactic Acid, fl^j 
Magma of freshly Precipitated Phosphate 
of Lime, q. s. 
Aqme FI. Aurant., fi^iss 
Aquas Pune, q. s. ad flSviij 
Saccliari Albi, 3xj. 
Mix the lactic acid with 2 fluid ounces of water 
and saturate it with the magma. Put the liquid 
upon a filter and add the rest of the water until 8 
fluid ounces of filtrate are obtained. Pour this upon 
the sugar, contained in a bottle; shake occasionally 
until solution is effected and strain. No heat ought 
to be applied, else the syrup assumes a milky ap¬ 
pearance. 
The syrup thus prepared contains between 2 and 
3 grains of dry phosphate of lime in each fl^, besides 
the lactic acid.— Amer. Journ. of Pharmacy. 
