76G 
THE PHARMACEUTICAL JOURNAL AND TRANSACTIONS. 
[March 23, 1872. 
thus enabled to observe a fact of some importance, that 
the salts of quinicine prepared from quinine are exactly 
similar in all their properties to those prepared from 
quinidine ; in fact, that there is hut one quinicine, from 
whichever of the isomeric bases it may have been de¬ 
rived. 
The chloroplatinate precipitated from a hot solution 
forms a crystalline powder; it can he obtained in 
definite crystals from a hot acid solution. Its formula 
is C 20 II 24 N 2 0 2 . 2 H CL Pt Cl 4 . Analysis gives the follow¬ 
ing results:— 
Pt. 
Chloroplatinate of alkaloid prepared 
from quinine.26*58 p. c. 
Chloroplatinate of alkaloid prepared 
from quinine.26*42 „ 
Chloroplatinate of alkaloid prepared 
from quinidine ....*... 26*45 „ 
Chloroplatinate of alkaloid extracted 
from quinoidine.26*63 „ 
Theory requires.26*76 „ 
The oxalate, as previously described, has the formula, 
2C 20 H 24 N 2 O 2 . C 2 H 2 0 4 + 9H 2 0. The analysis gives 
results as under :— 
O 
ct 
a 
n 
o 
H a O. 7 at. 
lost in vacuo. 
o 
O 
°5 O 
• 
O 03 
d 4-3 
K o 
Theory . 
10-00 
14-00 
18-00 
Average of previous determinations of oxa- 
late from quinoidine. 
10-11 
14-04 
17-91 
Oxalate of quinicine prepared from qui-> 
9-99 
14-37 
18-02 
nine.f 
— 
13-90 
18-05 
Oxalate of quinicine prepared from qui-i 
9*96 
14-08 
17-83 
nidine. ) 
14-00 
17-83 
The acid tartrate crystallizes freely from strong solu¬ 
tions in radiated needles; the determinations of H 2 0 
and C 4 H 6 0 6 agree with the formula, C 20 H 24 N 2 O 2 . C 4 H 6 0 6 
+ 6H 2 0. The salt fuses readily when exposed to a 
heat of 100° C. By gradual drying at about 50°, it 
loses 4 atoms of water; and by heating to 140°, the 
remaining 2 atoms are expelled, with fusion of the salt 
and slight discoloration. Analysis gives the following- 
figures :— 
quinicine pre 
pared) I. 
Theory .... 
Acid tartrate of 
from quinine 
Acid tartrate of quinicine prepared) I. 
from quinidine.f II. 
Acid tartrate of quinicine prepared^ I. 
from quinoidine.i II. 
o 
o 
e 
W 
+ 
o 
HjO. 4 at. 
lost at 50 c. 
HjO. 6 at. 
lost at 140 c. 
25-77 
12-37 
18-56 
26-05 
12-80 
19-36 
25-29 
13-00 
— 
25-26 
11-97 
19-31 
25-23 
11-83 
18-88 
25-97 
13-55 
17-99 
25-66 
13-00 
19-29 
Cinchonicine and its salts are very similar in their 
properties to quinicine and its salts; the alkaloid is 
soluble in ether, separating like quinicine, as an oily 
layer at the bottom of the solution as the ether evapo¬ 
rates. The salts are somewhat more soluble than the 
corresponding quinicine salts. The same identity is ob¬ 
served between those prepared from cinchonine and 
those from cinchonidine that is found between the salts 
of quinicine prepared from quinine and from quinidine. 
The platinochloride gives the following results, showing 
the formula to he C 20 H 24 N 2 O . 2HC1 . PtCl 4 :— 
Pt. 
Theory ..27*36 
Platinochloride of cinchonicine prepared ) 27*65 
from cinchonine.) 27*61 
Platinochloride of cinchonicine prepared \ 27*52 
from cinchonidine.j 27-63 
The oxalate differs from the oxalate of quinicine by 
containing only seven atoms of water; it very readily 
loses a portion of this water, and is therefore difficult to 
dry for analysis; the whole is given off at 100° C. No 
definite point of hydration is reached by drying in vacuo. 
It is somewhat more soluble than the quinicine salt. 
Analysis gives the following results :— 
2C 20 H 24 N 2 O . C 2 H 2 0 4 + 7H 2 0 require— 
C a H 2 0 4 , 
10-82. 
7 H a O. 
15-14 
Oxalate of cinchonicine prepared from cin-^ 
chonine gives. 
Oxalate of cinchonicine prepared from cin- 
11-06 
10- 90 
11- 07 
11-00 
11-05 
14- 30 
15- 18 
14-76 
15.55 
The acid tartrate crystallizes in crusts composed of 
short prisms; this salt contains hut one atom of water, 
which it loses at 120° C. without fusion. 
The formula, C 20 H 24 N 2 O . C 4 H 6 0 6 + H 2 0 requires— 
c 4 h 6 o 0 . 
31*51. 
H.O. 
3-70. 
Acid tartrate of cinchonicine prepared "i 
from cinchonine gives . .. * 
Acid tartrate of cinchonicine prepared \ 
32-49 
31- 33 
32- 27 
3-83 
3-80 
3-68 
The action of these alkaloids on polarized light also 
shows the identity of the resulting alkaloid produced by 
the action of heat on the isomeric alkaloids, the dif¬ 
ferent action on the polarized ray disappearing with the 
other characteristic distinctions. Quinicine, either from, 
the strongly levogyrate quinine, or from the dextrogyrate 
quinidine, exhibits a comparatively feeble right-handed 
rotation, identical within the limits of errors of observa¬ 
tion. 
The observed molecular rotatory powers of these alka¬ 
loids for the yellow ray are as follows:— 
In a spirituous solution of the alkaloid— 
Quinicine from quinine .... 8 39 
Quinicine from quinidine .... 8 39° 
Quinicine from quinoidine . . . 8 39-3° 
Oxalate of quinicine in an acid solution— 
Prepared from quinine . . . . c? 13‘4° 
Prepared from quinidine . . . . 8 14° 
Prepared from quinoidine . . . 
Cinchonicine in a spirituous solution:— 
Prepared from cinchonine . . . 8 48° 
Prepared from cinchonidine . . . 8 48*4° 
Oxalate of cinchonicine in an acid solution— 
From cinchonine.<? 18° 
From cinchonidine. 8 17*9° 
It will he observed that the rotatory power in both 
cases is much less in an acid solution than in a spirituous 
solution of the alkaloid. 
It is very difficult to determine what is the exact 
nature of the change we have been considering. The 
examination of the optical and chemical properties of 
successive crystallizations of these salts fails to detect 
signs of the existence of more than one homogeneous 
product. The high colour of some of the later crystal¬ 
lizations prevented the use of solutions in the polari- 
meter strong enough to give more than a very small 
angle of rotation, and perfectly accordant results are 
thus unattainable. Still the differences observed be¬ 
tween the first and the last crystallizations from con¬ 
siderable quantities are too small to throw doubt on 
their identity. 
Thus the molecular rotation observed in the oxalate of 
quinicine from the mother-liquor of salts of the alkaloid 
prepared from quinine was 8 13*3°, and of the alkaloid 
in solution in spirit 8 31*6° ; that of similarly prepared 
oxalate from quinidine 8 12*2°. Cinchonicine from the 
