-June 15, 1872.] 
THE PHARMACEUTICAL JOURNAL AND TRANSACTIONS. 
1011 
that of the iron solution within the bladder. This 
exterior water is changed during the first few days every 
twelve hours, and later, every twenty-four. Well-water 
■cannot replace distilled water during the first few days. 
The first diffused liquors, rich in ferric chloride, can be 
-employed for the precipitation of the ferric oxide. The 
diffusion is continued with distilled water until, after 
■one lasting twenty-four hours, nothing is dissolved, 
which upon the addition of nitric acid will be precipita¬ 
ted by argentic nitrate. In ten or fourteen days this | 
result will be achieved. The iron solution contained in 
■the bladder I suggest to dilute to 1000, when it will 
contain about 5 per 'cent, of the ferric hydrate of the 
■above composition. Should too much water have entered 
the bladder, the liquor may be concentrated in a water- 
bath (or better, air-bath), at a temperature of 60° or 70° 
C. In most cases, part of the colloidal ferric oxide will 
during this process be changed to the normal oxide, and 
will separate. 
The liquor ferri dialysati is best used without any 
addition, which is easily possible, as it is tasteless. Its 
■dilution is only permissible with distilled water. Well- 
water at once causes a precipitate of the ferric oxide. 
Even the patient using the iron should drink distilled 
water afterwards, if he thinks it at all necessary. If the 
preparation is to be sweetened, this may be done with 
simple syrup. Sufficient white sugar may also be added 
to produce a syrup, but the solution of this sugar must 
take place at the ordinary temperature. If the solution 
is attempted at an elevated temperature, frequently a 
part or all the ferric oxide will separate from the solu¬ 
tion, especially if the sugar be not perfectly white and 
free from lime. 
The liquor ferri dialysati keeps well. I have pre¬ 
served a sample solution of the same over four years, 
without having noticed any change. Also a sample of 
syrupus ferri dialysati , prepared by dissolving 120 parts 
of powdered sugar in 75 parts of the liquor, I have kept 
for several years without any apparent change. 
Orossinger has already called attention to the stability 
of such a syrup. I claim a superiority of these solu¬ 
tions of dialysed iron over those prepared by Hager’s 
method, as mine contain less ferric chloride than Hager’s. 
His proportion between muriatic acid and iron is 13:7. 
Tor children and weakly persons, I deem my prepara¬ 
tion more useful. 
A liquor ferri phosphorici dialysati , I prepare by mix¬ 
ing an aqueous solution of the officinal sodic phosphate 
with an aqueous solution of ferric chloride, and subse¬ 
quent diffusion. After completion of this process a light 
brown solution is obtained, containing 3 per cent, ferric : 
phosphate. The proportion of ferric oxide and phos- j 
phoric acid was established as 3 eq. to 1 eq. 
This solution also is tasteless, and may be especially 
.applicable for therapeutic use, possesing the merit over 
■the solutions of ferric phophate ordinarily used of con¬ 
taining common orthophosphoric acid i. e. } phosphoric 
acid in the shape in which the animal body can best 
.assimilate it. Also from this liquor I prepared a syrup 
by the addition of sugar in the above proportion. But 
this commenced to show decomposition in about two 
weeks. The liquid became gelatinous, and acquired an 
inky taste. After three or four months numerous algie 
were found in the mixture.— The Chicago Pharmacist. 
CONTRIBUTIONS TO THE HISTORY OF THE 
OPIUM ALKALOIDS. 
BY C. R. A. WEIGHT, D.SC. 
(Concluded from page 992.) 
IV. Action of Sulphuric Acid on Codeia and its 
Polymer ides.. 
The results detailed in the previous sections show that 
Ihe action of sulphuric acid on codeia is to polymerize it, 
with the formation of di-, tri-, and tetracodeia, the sub- j 
stances obtained by Armstrong and by Anderson by this 
means being identical with the first and last of these 
bases; it appears probable that tetracodeia may be 
formed by the further polymerization of dicodeia, whereas 
it would seem as though tricodeia were not likely to be 
obtained from dicodeia; on the other hand, it is possible 
that tetracodeia is directly produced from codeia, and 
that it could not be formed from dicodeia. To settle 
this point, pure dicodeia was heated to very gentle 
1 ebullition with sulphuric acid diluted with its own bulk 
of water for five hours, the operation being conducted 
in a long-necked flask so that no appreciable concentra¬ 
tion by evaporation took place. At the end of this time 
the dicodeia was wholly converted into a base, of which 
ether dissolved only traces; hence no tricodeia was 
formed. After precipitation by Na 2 C0 3 and drying, the 
free base "was dissolved in alcohol and fractionally pre¬ 
cipitated by ether. If the alcoholic solution be nearly 
free from water, the ether throws down solid amorphous 
flakes ; but if ten or more per cent, of water be present, 
the ether precipitate is a tarry fluid containing water, 
alcohol, and the base. Flakes of tetracodeia were thus 
obtained identical in all respects with that obtained by 
the action of phosphoric acid; a trace of some product 
of the further action of sulphuric acid appeared to be 
present, however, as the free base turned slightly green 
on drying, without, however, absorbing so much oxygen 
as to make any appreciable difference in its composition. 
Dried at 100°, 0 - 221 grm. gave 0-583 C0 2 and 0T42 H 2 0. 
Calculated. Found. 
C 144 . 1728 72-24 71-94 
H 10S . 168 7-02 7-14 
N 3 . 112 4-68 
Oo 4 . 384 16-06 
C 144 H 16S N 8 0 24 2392 100-00 
If the action of sulphuric acid be pushed further than 
this point, a smell of S0 2 is perceptible, and the pro¬ 
duct obtained rapidly oxidizes on precipitation by Nag 
C0 3 and exposure to air. Nothing fit for analysis was 
obtained from the product, which probably is formed by 
the dehydration, oxidation, and possibly de-methylization 
of tetracodeia. 
Y. On the Physiological Action of the foregoing Poly- 
mcrides. By Reginald Stocker, M.B., Pathologist in 
St. Mary's Hospital Medical School. 
An aqueous solution of the hydrochlorate of codeia 
and its polymerides was in each case employed, being 
subcutaneously injected into adult cats (a dog being also 
employed in a few experiments), quantities equivalent to 
0-1 grm. of the anhydrous salt being used in each experi¬ 
ment. Four cats were employed, several trials being 
made with each animal, and three or four days being 
allowed to intervene between each experiment, so that 
the effects of one dose had entirely passed away and the 
animal entirely recovered before the administration of 
another dose. The main results observed were as 
follows:— 
Codeia. —Four experiments. In each instance dilated 
pupils ; cerebral congestion (determined by ophthalmo¬ 
scopic examination), and much increased reflex . excita¬ 
bility (epileptic convulsions in one case); salivation and 
purging in two cases; vomiting not j>roduced in any 
case. 
Bicodeia. —Two experiments. In each instance vomit¬ 
ing ; fundus of eye not congested; pupil dilated in one 
case. 
Another experiment with a dog_ (full-grown she- 
terricr) produced salivation and purging without vomit¬ 
ing ; no cerebral congestion. 
Tricodeia. —Three experiments. In each case saliva¬ 
tion (profuse) and dilated pupils; no cerebral congestion; 
in one case slight excitement; in the others purging and 
depression; vomiting produced in one of these two latter 
instances, micturation in the other. 
