336 
MR. E. P. FRANCE ON DEGENERATIONS WHICH FOLLOW LESIONS 
Record of Cases Investigated, showing in each Case the Situation and 
Extent of the Cerebral Lesion, the Symptoms Observed during Life, 
AND THE Degenerations which were found to have Resulted from the 
Lesion. 
Case 1.— No. 11 of First Series.^’' (Figs. la to le, Plates 27 and 28.) 
Le sion .—Removal of a longitudinal strip of grey matter from the left side of the 
brain, along the margin of the longitudinal fissure from the level of the anterior end of 
tiie prsecentral nearly to the parieto-occipital fissure (fig. \a in surface view, fig. lb in 
section). 
Result. —Some paralysis of both right iimbs, which gradually became less evident in 
the arm; the leg paresis was ^permanently obvious. This Monkey was killed one year 
after the operation. 
Degenerations 0hserned. 
Pons .—There is a difference in the appearance of the two sides, the pyramidal 
bundles on the left side being stained with aniline blue-black more darkly than on the 
right, and appearing smaller. 
Medulla. —Here the naked eye appearance of the pyramid of the left side is difterent 
from that of the right, being smaller and more deeply stained. 
Microscopically, the left pyramid is considerably degenerated and sclerosed, although 
there are a great many healthy fibres scattered about in it. 
Sjnnod Cord. Cervical Enlargement .—Sections here show degeneration, with 
sclerosis, in the crossed pyramidal tract on the right side (see fig. Ic), extending from 
the posterior root outwards and forwards til] it reaches the circumference at about the 
middle of the lateral surface. The degeneration is claw-shaped, with the root of the 
claw at the posterior cornu, the convex side tosvards the direct cerebellar tract, and 
the tip at the surface of the cord. 
The crossed pyramidal tract is not entirely degenerated, that part only ndnch is 
adjacent to the direct cerebellar tract being affected, the anterior part having remained 
healthy. There is some degeneration on the same side as the lesion in a similar 
position to that on the opposite side. 
No degeneration can be seen in the anterior median column on either side either 
in this case or in any other which has been examined by me. 
Dorsal Region. —Here the degeneration is narrower than in the cervical region, 
* The series of experiments recorded by Horsley and Schafer (loc. cit.) will be referred to as the First 
Series; those recorded by Sanger Brown and Schafer (he. cit.) as the Second Series. Further illustra¬ 
tions of the extent and depth of the several lesions are to be found in the plates accompanying those 
papers. 
