409 
THE DRUG TREATMENT OF CANINE 
PIROPLASMOSIS. 
By GEORGE II. F. NUTTALL, M.D., Ph.D., Sc.D., F.R.S., 
Fellow of Magdalene College, Quick Professor of Biology, Cambridge. 
CONTENTS. 
PAGE 
1. Some earlier work by Italian investigators . . . 409 
2. Further experiments with aniline dyes .... 413 
3. The Continued Infeotivity of the blood of dogs which have 
recovered from piroplasmosis.419 
4. Trypanblue treatment: confirmatory results obtained in 
Cape Colony.426 
5. Summary and conclusions.430 
6. References.434 
1. Some Earlier Work by Italian Investigators. 
BEFORE describing my further results in the treatment of canine 
piroplasmosis by aniline dyes, I desire to mention some earlier experi¬ 
ments, carried out by Italian investigators whose papers have until 
recently escaped my attention. The results of the Italian experiments 
are cited in considerable detail with a view to making it unnecessary 
for other workers to refer to the original papers which may be difficult 
of access. It is well to note that the authors in question give very 
little information concerning their experiments; thus Memmo, Martoglio 
and Adani are satisfied with giving mere clinical notes, whilst Levi 
della Vida omits a number of essential data from his protocols. 
Attempts to cure the disease by artificially induced Leucocytosis: 
treatment with Quinine, Oil of Turpentine, Sodium nucleinate. 
Memmo, Martoglio and Adani (1905, p. 23), who observed canine 
piroplasmosis at Cassala in Eritrea, state that before the nature of the 
disease was recognised in that part of Africa “anaemia of dogs” used to 
