410 Treatment of Canine Piroplasmosis 
be treated with antihelminthics and by subcutaneous injections of ferru¬ 
ginous preparations. They treated two dogs by subcutaneous injections 
of quinine and the animals recovered, abscesses having formed at some 
of the places whei’e the injections had been made. They cite the 
experience of Mozzetti, who stated that he had found recovery to take 
place more readily in dogs in whom abscesses had developed following 
upon subcutaneous injections of drugs. Mem mo, Martoglio and Adani 
thereupon decided to try if the artificial production of abscesses in dogs 
would exert an influence upon the course of the disease. They appear 
to have had striking results, for 12 dogs with piroplasmosis in which 
abscesses were produced all recovered. The dog suffering from piro¬ 
plasmosis received 5 to 10 drops of pure oil of turpentine injected sub¬ 
cutaneously in the pectoral region. The injection produced a violent 
local reaction and considerable fever. The abscess which developed at 
the seat of injection was lanced after 2—3 days, after which the tempera¬ 
ture fell rapidly, the animal’s condition improved, the blood again became 
normal and the dog recovered completely. They proposed to try the 
treatment on cattle. 
Our exact experiments (Nuttall and Graham-Smith, 1908, p. 121) 
have demonstrated that quinine is ineffective in the treatment of the 
disease and those of Levi della Vida (1907, p. 359), with turpentine, 
gave results contrary to Memmo, Martoglio and Adani’s. Levi della 
Vida inoculated 3 dogs with piroplasmosis, and after 3 to 4 days he gave 
each dog a subcutaneous injection of '5 c.c. of oil of turpentine. The 
dogs had marked leucocytosis (12,000 to 15,000 per c.mm.) following 
upon the turpentine injections, but they all died of piroplasmosis within 
the usual time, 5 to 8 days, after inoculation. 
Levi della Vida likewise induced leucocytosis in two dogs through 
intraperitoneal injections of sodium nucleinate (3 c.c. of a 3 °/o solution). 
The results were negative and similar to those obtained with tur¬ 
pentine. 
Attempts to cure canine piroplasmosis by means of Atoxyl , Fowler's 
solution, Sodium cacodylate, Methylene blue, Brilliant green, 
Trypanred, and Dichlorobenzidine + 2 mol. of Amido-naphthol- 
disulpho. 
Levi della Vida (1907, p. 359), working with a strain of canine piro¬ 
plasmosis obtained from Hamburg, attempted to cure the disease by 
means of various drugs as follows : 
