GT. H. F. Nuttall 
411 
Atoxyl. The results obtained with atoxyl treatment are contrary to 
those of Gonder (1908) which we have fully described elsewhere (This 
Journal, Yol. I. p. 223). Levi della Vida (p. 360) does not mention the 
number of experiments he performed on dogs, whereas Gonder gives full 
details of six cases treated with negative results. Levi della Yida states 
that he gave his dogs 0'20 centigrammes of atoxyl every day, the treat¬ 
ment commencing 48 hours after inoculation. Parasites never appeared 
in the atoxyl-treated dogs, whereas untreated control dogs died of piro- 
plasmosis. The atoxyl-treated dogs subsequently proved to be suscep¬ 
tible to piroplasmosis when reinoculated. One dog, which received less 
atoxyl than the amount stated, was not cured. This is all that the 
Italian author has to say about his experiments, consequently little 
value can be attached to them, especially since they are contrary to the 
carefully conducted experiments reported by Gonder. There is no 
evidence that atoxyl exerts any curative effect upon the disease when 
clinical symptoms have developed. 
Two dogs were similarly treated with Trypanred (0'25 gramme), the 
one after the parasites had appeared in the blood, the other at the time 
when it was inoculated; this dye likewise exerted no apparent effect 
upon the course of the disease. (This result is contrary to those 
obtained by Nuttall and Hadwen, vi. 1909, p. 172, in which a dog was 
cured by means of this dye, and the degeneration of the parasites was 
observed in two dogs in consequence of tlie treatment.) 
Levi della Vida (p. 360) records that Dichlorobenzidine + 2 molecules 
of Amido-naphthol-disulpho (Friedr. Bayer and Co., Elberfeld) may at 
times exert a curative action. In two dogs which received 0T6 gramme 
of’this dye daily on four successive days, beginning with the day when 
parasites appeared, the disease was promptly arrested; the parasites 
grew scarcer and finally disappeared. The blood of these dogs was 
found to be infective after one and two months had elapsed. Whereas 
one dog showed a fall in the number of red blood-corpuscles the contrary 
was the case in the other animal; both showed leucocytosis (10,000 
per c.mm.); neither of them had jaundice or haemoglobinuria, whilst in 
both the temperature fell to normal after the first few days. Both of 
these dogs were moderately young. When the treatment was tried on 
8 puppies, 2 to 3 months old, all of the animals died of piroplasmosis. The 
dye was given in doses of 10 to 15 centigrammes per day, treatment 
commencing at different times following upon inoculation. The dye 
exerted a parasiticidal effect in vitro, for virulent blood exposed for 15 
