G. H. F. Nuttall 
429 
II. Records of Clinical Cases. 
The following records refer only to dogs, six in number, which 
acquired the disease under natural conditions, i.e. by means of infected 
ticks. The dogs were handed over for treatment when very ill, two of 
them were moribund. “The remainder (four) were very well-marked 
cases, and we fully believe that had they not received the trypanblue 
treatment all these animals would have succumbed to the malady.” 
In Jowett’s experience, natural recovery “is very rare indeed,” and he 
inclines to the belief that the disease arising from infection through 
ticks is more severe than that following upon inoculation with blood. 
Dogs 1 and 2 treated when moribund. One died 2 hours after treatment, the other 
after 24 hours. 
Dog 3. Fox-terrier. Weight 14| lbs. Had been sick for some days, very ill on 
admission, temperature 104-4° F., haemoglobinuria present, parasites found. Treatment: 
5 c.c. sat. sol. of trypanblue subcutaneously. 1st day after treatment, temperature 101— 
104-2° F., very ill, no parasites found. 2nd day, 102—102-8° F., much better, painful 
swelling at seat of drug-injection. 3rd day, 102—100-8° F., “quite lively and well,” 
swelling lanced. From now on to the 28th day there were occasional rises of temperature. 
Infected r.b.c. were again noted on the 17th (0-7 %), 18th and 19th days. 
Dog 4. Irish terrier. Weight 32 lbs. Obviously ill on arrival, 7 to 8 infected r.b.c. 
per film, temperature 103-6°, anaemia and haemoglobinuria present. Treatment .- 10 c.c. 
of sat. sol. of trypanblue. 1st day after treatment very ill, weak and staggering, terribly 
anaemic, temperature 95—98-4°, no parasites found. Treatment: 2 c.c. of sat. sol. 
trypanblue after subcutaneous injection of 200 c.c. of normal NaCl solution. 2nd day, 
no parasites, dog better, temperature 101-2°. 4—6th day, dog improved, slough at seat 
of drug-injection ; no parasites found. 
Dog S. Airedale terrier. Weight 35 lbs. Very ill on arrival, parasites found, haemo¬ 
globinuria present. Treatment: 13 c.c. of sat. sol. of trypanblue subcutaneously. “Parasites 
disappeared with a corresponding improvement in the dog’s condition.” Swelling at site 
of injection subsequently lanced. “ The dog is now progressing satisfactorily.” 
Dog 6. Newfoundland. Weight 65 lbs. Very ill indeed on arrival, had been ill a 
week, parasites found in fair numbers; haemoglobinuria present. Treatment: 20 c.c. of 
sat. sol. of trypanblue intravenously. 1st day after treatment slightly better, only 1 (PP) 
infected r.b.c. found in film, blue colouration of dog only slight; treatment repeated: 
5 c.c. of dye solution again injected. No swelling formed at site of dye-injection. “ At 
the time of writing the animal is progressing satisfactorily towards recovery.” 
