430 
Treatment of Canine Pirop lasmosis 
Summary of Jowett’s results in the treatment of 
Canine Piroplasmosis with Trypanblue. 
I. Experimental cases. Six dogs, inoculated with virulent blood 
and afterwards treated with trypanblue, all recovered. Four control 
dogs (untreated) all died. One dog which received trypanblue by the 
mouth also died. One dog treated 3 days after inoculation remained 
well and never showed parasites. One dog which received a dose of 
trypanblue and which was inoculated six days later, remained well. 
II. Clinical cases. Two dogs in which treatment was attempted 
when moribund died. Four dogs, very ill and manifesting severe 
symptoms of piroplasmosis (anaemia, haemoglobinuria, icterus), all 
recovered after treatment with trypanblue. 
I would note that the period of observation after treatment has been 
very short in a number of Jowett’s cases and that some of the animals 
may have since had a relapse, such as we observed in two of our dogs 
(Nos. 10 and 11, pp. 184—186, this volume) 1 . 
5. Summary and Conclusions. 
The following summary and conclusions apply to the results of the 
experimental treatment of canine piroplasmosis by various authors 
including myself: 
1. Drugs which have been found ineffective in the treatment of 
canine piroplasmosis are: 
Arsacetin tested on 1 dog by Nuttall and Had wen (1909, p. 158). 
Soamin tested on 1 dog by Nuttall and Hadwen (1909, p. 158). 
Sodium-methylar senate tested on 2 dogs by Nuttall and Graham- 
Smith (1908, p. 222). 
Tartar emetic tested on 2 dogs by Nuttall and Graham-Smith 
(1908, p. 221). 
Sodium nucleinate tested on 2 dogs by Levi della Vida (1907, 
p. 359). 
1 In a short paper, which has just appeared, Jowett (25. xii. 1909) does not record any 
relapses. He states that the treatment has “more than realized our expectations.” The 
paper referred to concerns itself with the dosage and the method of injecting the dye and 
was written with a view to informing veterinarians at the Cape regarding the treatment. 
The paper does not contain anything new. See my note on the solubility of the dye 
(Parasitology , ii. p. 266): Jowett now uses 1—2 °/ 0 solutions of Trypanblue (filtered in the 
latter case); the solutions are made up with boiling water. 
