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spores of the former have caused a secondary infection of the surrounding 
tissue (PL XVIII, fig. 2). Occasionally the spores are disseminated 
throughout the connective tissue, without being enclosed within a 
cyst-wall (PL XVIII, fig. 4). This condition was called by Dofiein 
(1909) “diffuse infiltration.” The cysts may exceed 1’44 x 0’82 mm. in 
size, but some of them are much smaller with a diameter of 11-49 /a. 
Diagram I. Trophozoites of P, gigantea. (Oil immersion 2 mm. ocul. No. 4.) Mono, 
and multinucleate individuals surrounded by connective tissue, a. Aggregation of 
3 individuals, h. Stage of division. 
