[ i8 ] 
\\ as no excess of saliva in the mouth, and no appearance of weakness or loss 
5 f rr C °T ro1 - ° Ver mov . ement - , The appetite was poor, but there was no 
dimculty. in swallowing. No more definite signs supervened, but next 
evening it refused food and died on the following morning, 3 days after its 
short period of excitement. 
. The diagnosis of rabies was shown to be the correct one by the result 
0 ln _tradural injection into a rabbit by Dr. Braddon, and subsequentlv at 
the Institute Pasteur de Saigon by injections from a portion of the brain 
or the dog sent there by Dr. Braddon. 
In the cases under observation similar deviations from the usually 
described forms of the disease occurred. In only one was there excess of 
sain a discharged from the mouth. In only one was there definite paralysis. 
I he stage of excitement in most of them had probably been manifested 
betore admission as the dogs had bitten other dogs or people but was either 
not present whilst under observation or was only present during a brief 
period wnich in two cases was late in the disease on the day of death, and in 
another on the third day over 24 hours before death. Loss of appetite, 
complete before death, was the only constant symptom. Death occurred' 
in all cases and m from 3 to 5 days after the animal was first suspected of 
being ill. Se\ eral of the other dogs under observation showed more violent 
dispositions than those dogs shown to have rabies. 
The diagnostic value of intradural injections was clearly shown. 
There are difficulties connected with it, as rabbits in the tropics appear more 
liable, to disease, do not breed so fast, and are more difficult to rear 
than in temperate climates. Putrefaction is so rapid that unless a dog has 
been killed or died within a few hours of the examination the rabbits 
injected frequently die of septicaemia. 
The virus of hydrophobia appears to be in a somewhat attenuated 
form in ^ Malaya. The usual period of death after intradural injection 
m the raobit was 17 to 18 days, and the earliest 15 days. As in Europe, 
the \ irus is intensified in passing through the rabbit, and the period after 
an intradural injection from one rabbit into a second rabbit was reduced to 
12 to 14 days. Third injections were not performed on account of the 
scarcity of male rabbits. 
A point of importance is the small number of cases in which the doo-s 
bitten developed rabies. Out of a considerable number believed or known 
to have been bitten by these rabid dogs only 4 are known to have in turn 
become rabid, and the others, many of them under careful observation, have 
show n no signs 01 the disease. Of the four who developed the disease after 
being bitten by rabid dogs in two the period was rather short, 20 and 
25 days respectively. 
None of the human beings bitten by the dogs have developed 
rabies. Most of them were sent to the Pasteur Institute, SaDon, for 
treatment. 
. The rarity of the cases in which dogs bitten by the rabid dogs developed 
rabies, may be.due to the usual absence of salivation in the local variety 
01 rabies. It is noteworthy that at the post-mortem examinations on the 
rabid dogs no marked enlargement or congestion of the salivary glands was 
found. 
\\ hether rabies is endemic or not amongst dogs in the country cannot 
be stated. The occasional appearance of a group of cases with a long 
inter\ al between, favours the supposition that it is not endemic, but imported 
