J. D. E. Holmes 
85 
Effect of atoxyl administered by the mouth. 
The treatment was commenced when trypanosomes were numerous 
in the blood. 
Pony no. 50. 300 lbs., received 4-8 gms. atoxyl in bolus (8 gms. per 500 lbs.). Pony 
was off feed for three days. No effect on trypanosomes. On seventh day received another 
4 gms. atoxyl. No effect on trypanosomes. On ninth and eleventh day 4 gms. atoxyl 
were given, the number of trypanosomes in blood continued to increase. Treatment 
discontinued. 
Pony no. 51. 229 lbs., treatment commenced on 5th day of disease. Received 
2 29 gms. atoxyl in bolus (5 gms. per 500 lbs.). Pony was off feed for two days. No 
effect on trypanosomes. 
Pony no. 52. 300 lbs., received 6 gms. atoxyl in bolus (10 gms. per 500 lbs.). Pony 
died in 17 hours. 
Atoxyl administered by the mouth is about five times less toxic than 
ai’senious oxide, but has no effect on the trypanosomes in the blood. 
Effect of atoxyl injected subcutaneously. 
A four per cent, solution of atoxyl was used except where otherwise 
stated. 
Pony no. 53. 240 lbs. (intermittent dosage). 
1st day received 50 c.c. 
9th day received 40 c.c. 
3rd ,, 
„ 50 „ 
11th „ 
» 40 „ 
5 th ,, 
„ 40 „ 
13th „ 
„ 40 „ 
7th „ 
40 „ 
Trypanosomes disappeared on 2nd day, but reappeared on 14th day. 
Pony no. 54. 400 lbs. (intermittent dosage). 
1st day received 50 c.c. 7th day received 50 c.c. 
3rd „ ,, 50 ,, 9th „ „ 50 ,, 
5th ,, ,, 50 ,, 
Ti’ypanosomes disappeared on 2nd day, but reappeared on 11th day. 
Pony no. 55. 564 lbs. (continuous dosage). 
1st day 
received 
50 c.c. 2 °/ 0 solution 
8th day received 100 c.c. 8 °/o solution 
2nd „ 
9 9 
50 ,, 2 ,, 
9 th 
99 
99 
100 „ 8 „ 
3rd ,, 
' 99 
50 ,, 4 ,, 
10th 
9 9 
99 
100 „ 8 
4 th „ 
99 
50 ,, 4 ,, 
11th 
99 
99 
100 „ 8 „ 
5 th „ 
99 
50 „ 4 „ 
12th 
99 
99 
100 „ 8 „ 
6th „ 
9 9 
50 ,, 4 ,, 
13th 
9 9 
9 9 
100 „ 8 „ 
7th ,, 
99 
100 ,, 8 
14th 
99 
9 9 
100 „ 8 
Trypanosomes disappeared on the 2nd day, reappeared 30 days after 
the treatment was discontinued. 
