J. D. E. Holmes 
87 
The effect of a single full dose administered at a period of paroxysm: 
Arsenious acid (in bolus). 
Pony no. 62. 
tion for 34 days. 
Pony no. 63. 
for 14 days. 
Pony no. 64. 
for 10 days. 
Pony no. 65. 
Mule no. 66. 
Pony no. C 7. 
tion 5J months. 
Pony no. 68. 
Pony no. 69. 
Pony no. 70. 
for 12 days. 
300 lbs., dose 1 gm. 
350 lbs., dose 1 gm. 
300 lbs., dose 1 gm. 
350 lbs., dose 1 gm. 
500 lbs., dose 2 gms. 
300 lbs.,dose 1 gm. 
300 lbs., dose 1 gm. 
300 lbs., dose 1 gm. 
281 lbs., dose 1 gm. 
The trypanosomes were absent from the circula- 
Trypanosomes disappeared from the circulation 
Trypanosomes disappeared from the circulation 
Trypanosomes disappeared for 23 days. 
Trypanosomes disappeared for 10 days. 
No return of trypanosomes. Kept under observa- 
Trypanosomes disappeared for 21 days. 
Trypanosomes disappeared for 14 days. 
Trypanosomes disappeared from the circulation 
Arsenious acid solution. 
Pony no. 71. 225 lbs., received 800 c.e. Trypanosomes disappeared for 10 days. 
Mule no. 72. 500 lbs., received 1200 c.c. Trypanosomes disappeared for five days. 
Arsenious acid (continuous treatment). 
Pony no. C 8. 350 lbs., 1st paroxysm. 14th day of disease. 
1st day 1 gm. ars. ac. 
11th day 2 gms. ars. ac. 
3rd „ 1 
13th „ 1 gm. „ 
5th ,, 1-2 gms. ars. ac. 
15th „ 1 
7th „ 1-5 
17th „ 1 „ 
9th ,, 1-5 ,, 
19th „ 1 
No return of trypanosomes. Kept under observation 3j months. 
Pony no. C 4. 350 lbs., 3rd paroxysm. 
20th day of disease. 
1st day 1 gm. ars. ac. 
7th day 1 gm. ars. ac. 
3rd „ 1 
9th „ 1 
5th „ 1 
Treatment stopped as pony was 
off feed and had an attack of colic. 
No return of trypanosomes. Kept under observation 3 months. 
Pony no. C 6. 300 lbs., 3rd paroxysm. 
19th day of disease. 
1st day 1 gm. ars. ac. 
11th day 1*5 gms. ars. ac. 
3rd „ 1 ,, 
13th „ 1-5 ,, 
5th „ 1 
15th „ 1-5 
7th „ 1 
17th „ 1-5 
9th ,, 1 ,, 
19th „ 2 
No reappearance of trypanosomes. Kept under observation 10^ 
months. 
