J. D. E. Holmes 
91 
Pony no. 89. 500 lbs., 2nd paroxysm. 18th day of disease. This pony had received 
previous treatment which failed. (Intermittent dosage.) 
1st day 70 c.c. atoxyl. 
3rd ,, 2 gms. ars. ac. 
5th ,, 100 c.c. atoxyl. 
7th ,, 1 gm. ars. ac. 
9th ,, 100 c.c. atoxyl. 
11th day 1 gm. ars. ac. 
13th ,, 100 c.c. atoxyl, 
15th ,, 1 gm. ars. ac. 
17th ,, 100 c.c. atoxyl 
19th ,, 1 gm. ars. ac. 
Trypanosomes disappeared after the first dose, but reappeared 8 days 
after the last dose. 
Pony no. 90. 560 lbs. (Intermittent dosage.) 
1st day 50 c.c. atoxyl. 
3rd ,, 0-5 gm. ars. ac 
5th ,, 50 c.c. atoxyl. 
7th ,, 2 gms. ars. ac. 
9th ,, 75 c.c. atoxyl. 
11th day 2 gms. ars. ac. 
13th ,, 50 c.c. atoxyl. 
15th ,, 2 gms. ars. ac. 
17th ,, 50 c.c. atoxyl. 
19th ,, 2 gms. ars. ac. 
Trypanosomes disappeared after the first dose, but reappeared 28 
days after the last dose. 
Pony no. 91. 280 lbs., 1st paroxysm. 
1st day 50 c.c. atoxyl. 
3rd ,', 1 gm. ars. ac. 
5th ,, 50 c.c. atoxyl. 
6th day of disease. (Intermittent dosage.) 
7th day 1 gm. ars. ac. 
9th ,, 50 c.c. atoxyl. 
11th ,, 1-5 gms. ars. ac. 
Trypanosomes disappeared after the first dose, but reappeared 21 
days after the last dose. 
Pony no. 92. 500 lbs., 1st paroxysm. 4th day of disease. (Simultaneous dosage.) 
1st day 40 c.c. atoxyl and 2 gms. ars. ac. 
2nd „ 40 „ „ 2 ,, 
3rd „ 40 „ 2 ,, 
Trypanosomes disappeared on 2nd day, but reappeared 9 days after 
the last dose. 
Pony no. 93. 300 lbs., 1st paroxysm. 5th day of disease. (Simultaneous dosage.) 
1st day 20 c.c. atoxyl and 1 gm. ars. ac. 
2nd „ 20 „ „ 1 „ 
3rd „ 20 „ „ 1 ,, 
4th „ 20 „ „ 1 „ 
Trypanosomes disappeared after first dose, but reappeared 12 days 
after last dose. 
In the above seven cases of failure, pony no. 87 did not receive 
sufficiently large doses of ars. ac., a fact which was recognised by 
the result of latter experiments. Ponies nos. 89 and 80 had been 
previously treated with atoxyl alone and the trypanosomes had acquired 
