J. D. E. Holmes 
93 
Pony no. C 15. 220 lbs., 1st paroxysm. 
1st day 50 c.c. atoxyl. 
3rd ,, 1 gm. ars. ac. 
5th ,, 50 c.c. atoxyl. 
7th ,, 1 gm. ars. ac. 
9th „ 50 c.c. atoxyl. 
No return of trypanosomes. 
Pony no. C 12. 300 lbs., 1st paroxysm. 
1st day 50 c.c. atoxyl. 
3rd ,, 1 gm. ars. ac. 
5th ,, 50 c.c. atoxyl. 
7th ,, 1 gm. ars. ac. 
9th ,, 50 c.c. atoxyl. 
No return of trypanosomes. 
Pony no. C 14. 250 lbs., 1st paroxysm. 
1st day 50 c.c. atoxyl. 
3rd ,, 0 - 5 gm. ars. ac. 
5th ,, 50 c.c. atoxyl. 
7th ,, 0-5 gm. ars. ac. 
9th ,, 50 c.c. atoxyl. 
5th day of disease. (Intermittent dosage.) 
11th day 1 gm. ars. ac. 
13th ,, 50 c.c. atoxyl. 
15th ,, 1 gm. ars. ac. 
17th ,, 50 c.c. atoxyl. 
19th ,, 1 gm. ars. ac. 
Kept Under observation 13 months. 
4th day of disease. (Intermittent dosage.) 
11th day 1 gm. ars. ac. 
13th ,, 50 c.c. atoxyl. 
15th ,, 1 gm. ars. ac. 
17th ,, 50 c.c. atoxyl. 
19th ,, 1 gm. ars. ac. 
Kept under observation 10 months. 
1st day of disease. (Intermittent dosage.) 
11th day 05 gm. ars. ac. 
13th ,, 50 c.c atoxyl. 
15th ,,50 ,, 
17th ,, 0-7 gm. atoxyl. 
No return of trypanosomes. Kept under observation 14 months. 
Mule no. C 9. 300 lbs., 2nd paroxysm. 
1st day 50 c.c. atoxyl. 
3rd ,, 05 gm. ars. ac. 
5th ,, 50 c.c. atoxyl. 
7th ,, 1 gm. ars. ac. 
9th ,, 50 c.c. atoxyl. 
No return of trypanosomes. 
Mule no. C 10. 500 lbs., 2nd paroxysm. 
1st day 50 c.c. atoxyl. 
3rd ,, l - 5 gms. ars. ac. 
5th ,, 50 c.c. atoxyl. 
7th ,, 1-5 gms. ars. ac. 
9th ,, 60 c.c. atoxyl. 
13th day of disease. (Intermittent dosage.) 
11th day 1*25 gms. ars. ac. 
13th ,, 50 c.c. atoxyl. 
15th ,, 1-25 gms. ars. ac. 
17th ,, 50 c.c. atoxyl. 
19th ,, 1-5 gms. ars. ac. 
Kept under observation months. 
12th day of disease. (Intermittent dosage.) 
11th day 2 gms. ars. ac. 
13th ,, 60 c.c. atoxyl. 
15th ,, 2 gms. ars. ac. 
17th ,, 60 c.c. atoxyl. 
19th „ 2 gms. ars. ac. 
No return of trypanosomes. Kept under observation 7^ months. 
In the following 16 experiments the atoxyl and arsenious acid were 
administered on a different system. 
A dose of arsenious acid in solution (Loeffler and Ruehs) in drench 
was administered at a period of paroxysm, this was followed on consecu¬ 
tive days by a dose of atoxyl subcutaneously and a dose of arsenious acid 
in bolus. These three doses were repeated once or twice at intervals of 
