J. D. E. Holmes 
99 
The subcutaneous injections were not well absorbed and caused pain 
and swelling at the seat of injection. 
Calomel in full and continuous doses had no effect on the course of 
the disease. It was tested in several cases. 
The combination of atoxyl and mercury was also tested, but the 
results were inferior to those obtained by the use of atoxyl alone. 
Mercury and Atoxyl. 
Pony no. 105. 600 lbs. Spontaneous ease received for treatment. Was in an ad¬ 
vanced stage of the disease. Received on alternate days 50 c.c. of 8 °/ 0 atoxyl and 20 c.c. 
HgCl 2 (1 in 1000) both intravenously. Trypanosomes disappeared after the first dose. 
The treatment was continued for fifteen days but had little effect on the course of the 
disease. 
Trypanosomes reappeared in the circulation 5 days after the treatment 
ceased. 
Pony no. 106. 300 lbs., 4th paroxysm. 24th day of disease. Had been treated by 
another method which failed. The pony was treated for four months with atoxyl and 
mercury administered intravenously. A total amount of 150 c.c. of 4 °/ 0 atoxyl and 
195 c.c. of HgCl„ (1 in 1000) was given. 
The treatment had little effect. 
Treatment with Antimony Salts. 
Potassium antimonyl tartrate. 
Pony no. 107. Body weight 600 lbs., 2nd paroxysm. 100 c.c. of 1 °/ 0 solution. 
Trypanosomes were absent from the blood for seven days. 
Pony no. 108. Body weight 600 lbs., 3rd paroxysm. 100 c.c. of 1 °/ 0 solution. 
Trypanosomes were absent from the circulation for nine days. 
Pony no. 109. Body weight 630 lbs., 4th paroxysm. 25th day of disease. This pony 
was treated for six weeks receiving at intervals intravenous injections of potassium 
antimonyl tartrate 1 % solution. The total amount administered was 9‘2 gms. During 
the treatment the pony improved in condition and the circulation remained free from 
trypanosomes. The trypanosomes reappeared in the blood three weeks after the treatment 
ceased. 
Potassium antimonyl tartrate administered in bolus had no influence 
on the course of the disease. 
7—2 
