J. D. E. Holmes 
101 
Tartar emetic and arsenious acid solution. 
Arsenious acid (Loeffler and Ruehs’ solution) was given in drench, and 
tartar emetic 1 °/o solution was given intravenously. 
Pony no. 114. Body weight 300 lbs., 1st paroxysm. 3rd day of disease. 
1st day 25 c.e. tartar emetic. 11th day 300 c.c. ars. ac. sol. 
3rd ,, 300 ,, 
ars. ac. sol. 
13th 
7 7 
25 
77 
tartar emetic. 
5 th ,, 
25 „ 
tartar emetic. 
15th 
7 7 
300 
7 7 
ars. ac. sol. 
7th ,, 
300 „ 
ars. ac. sol. 
17th 
77 
25 
7 7 
tartar emetic. 
9 th ,, 
25 „ 
tartar emetic. 
19th 
J 7 
300 
7 7 
ars. ac. sol. 
The trypanosomes were absent during the period of treatment, but 
reappeared 6 days after the last dose. 
Tartar emetic, atoxyl and arsenious acid. 
Pony no. C 32. Body weight 660 lbs., 2nd paroxysm. 24th day of disease. This 
animal had received other treatment which failed. Atoxyl was given subcutaneously, 
tartar emetic intravenously and orpiment in bolus. 
1st day 150 c.c. of 4 °/ 0 atoxyl. 
3rd ,, 2 gms. of ars. ac. 
5th ,, 125 c.c. of 4 °/ 0 atoxyl. 
6th ,, 50 ,, 1 ,, tartar emetic. 
7th ,, 2 - 0 gms. of ars. ac. 
8th ,, 100 c.c. of 4 °/ 0 atoxyl. 
9th ,, 50 ,, 1 ,, tartar emetic. 
10th ,, 2-0 gms. of ars. ac. 
12th day 100 c.c. of 4 °/ 0 atoxyl. 
13th ,, 50 ,, 1 ,, tartar emetic. 
14th ,, 2-0 gms. of ars. ac. 
18th ,, 100 c.c. of 4 °/o atoxyl. 
19th ,, 50 ,, 1 ,, tartar emetic. 
20th ,, 2-0 gms. of ars. ac. 
21st ,, 100 c.c. of 4 °/ 0 atoxyl. 
No reappearance of trypanosomes in the blood after the second day. 
Kept under observation for 12 months. The curative effect was 
probable due to the atoxyl and arsenious acid. 
Tartar emetic, arsenious acid solution and arsenious acid. 
Arsenious acid (1 in 1000) solution was given in drench, arsenious 
acid in bolus and tartar emetic 1 °/ 0 solution intravenously. 
Pony no. 115. Body weight 280 lbs., 1st 
1st day 250 c.c. ars. ac. sol. 
2nd ,, 25 ,, tartar emetic. 
3rd ,, 1‘0 gm. ars. ac. 
7th ,, 300 c.c. ars. ac. sol. 
paroxysm. 7th day of disease. 
8th day 25 c.c. tartar emetic. 
9th ,, 300 ,, ars. ac. sol. 
10th ,, 25 ,, tartar emetic. 
11th ,, 1-0 gm. ars. ac. 
Trypanosomes were absent from the blood during period of treatment. 
They reappeared 15 days after the last dose. 
