H. W. Acton and W. F. Harvey 
229 
In Macacus rhesus, we found the street virus of the dog became 
exalted and fixed in this animal just as in the rabbit and guinea-pig 
(Pasteur, 1884); the dog (Marie, 1907 ; Lamb and McKendrick, 1909); 
the cat (Blasi and Russo-Travali, 1894) etc. 
In the first two passages in this species of monkey, the rabies was 
clinically of the furious type ; from the 3rd to the 6th passage, the 
symptoms commenced with fury and for the last 24 to 48 hours the 
animals were completely paralysed; from the 7th passage onwards the 
paralytic type alone was observed. The virus we used was derived from 
a dog but had undergone one passage in a rabbit. Negri bodies were 
seen both in the dog’s brain and in the rabbit’s brain ; cultures from 
the brain, heart blood and liver of the rabbit were sterile. The incuba¬ 
tion period in the rabbit was a somewhat short one (10 days), but on 
the other hand the first monkey inoculated showed an incubation period 
of 13 days. The virus used by Pasteur produced rabies in the first 
passage monkey in 11 days. 
In the monkey from the 4th passage onwards the incubation 
period fluctuated between seven and eight days—it is difficult to 
determine the earliest symptoms in the monkey. The incubation period 
of the rabbits inoculated from the monkeys showed a fixed virus in¬ 
cubation period from the 7th passage onwards. Table II gives the 
TABLE II. 
Street virus passage in Macacus rhesus. The virus was obtained from a dog 
suspected of rabies, and sent from Burma. Negri bodies were found in 
the dog’s brain: the rabbit inoculated from it showed signs of rabies on 
the \0th day and died on the IZth. Gidtures from the brain, liver and 
heart’s blood were sterile; Negri bodies were found in the rabbit’s Hippo- 
campus major. 
Weight of 
Rabbit 
Dog 
No. of 
monkey in 
Incub. . , 
Negri 
Cultures 
Type of 
Incub. . , 
Incub. . . 
passage 
grammes 
Death 
bodies 
rabies 
Death P®™"* 
Death 
1st 
3850 
13/14 
+ 
- 
Furious 
— 
— 
2nd 
4000 
10/11 
+ 
- 
J) 
— 
— 
3rd 
1920 
9/12 
+ 
- 
Mixed 
9/12 
4th 
2300 
7/9 
+ 
- 
8/11 
— 
5th 
3630 
7/9 
+ 
- 
> > 
8/12 
— 
6th 
3650 
8/11 
+ 
- 
} > 
8/10 
— 
7th 
5200 
7/10 
+ 
- 
Paralytic 
7/11 
— 
8th 
1800 
8/12 
-1- 
- 
)» 
7/10 
— 
9th 
3500 
7/12 
+ 
- 
5 > 
7/10 
— 
10th 
2050 
8/11 
- 
- 
5» 
7/11 
— 
11th 
2000 
1 8/11 
- 
- 
5 ? 
7/10 , 
— 
12 th 
3000 
7/10 
> » 
7/11 
8/10 
15—2 
