H. W. Acton and W. F. Harvey 
231 
The formation of Negri Bodies. 
In a previous memoir (1911) we may not have made it sufficiently 
clear that we considered that the granules, which we described as the 
commencing stage of the Negri body, were those described by some 
authors as the specific parasites of rabies, which, by the development of 
a veil around them, produced the Negri body. The granules regarded 
by us as consisting of nucleolar matter are of all sizes ranging from 
almost ultra-microscopic particles up to those of 1-2^ in diameter. 
We take this opportunity of making that meaning clear. We were 
further guilty of using the term “ Chlamydozoa ” rather loosely by 
seeming to make it include the older genera Neuroryctes, and Cyto- 
ryctes, but we intended it to apply, as far as the contentions in our paper 
went, to the description quoted from Hartmann on page 256 of our 
paper. We take this opportunity of thanking the author of the note 
appended to our article for pointing out our inaccuracy. 
TABLE IV. 
0 ) ^ 
Size of Negri bodies 
0 
N 
^ JS o 
^ a- 
Under 
1 ^ 
L 
25 /A 
3/A ZhfJ. 
4/x 
5/a 
6/4 7/x 
§ i 
S a 
a-" 
rH 
0 a 
H'” 
1 st 
1 
8 
8 
7 
11 
6 — 
8 
— 
— 1 
2-3 
50 
Brown 
2 nd 
12 
23 
12 
22 
2 
20 1 
13 
2 
— 1 
2-6 
108 
Brown to 
3rd 
20 
54 
26 
22 
4 
4 — 
2 
1 
1-4 
133 
black 
Brown 
4th 
23 
44 
26 
17 
2 
4 — 
_ 
_ 
_ _ 
1-2 
116 
Brown & 
5 th 
60 
23 
11 
7 
1 
2 — 
•9 
104 
black 
> J 
6 th 
97 
54 
11 
10 
2 
1 — 
— 
— 
— — 
•8 
174 
Black 
7th 
2 
1 
■6 
3 
J > 
8 th 
2 
2 
>> 
9th 
1 
1 
2 
)) 
10 th 
— 
11 th 
— 
12 th 
Our results on the study of Negri bodies in the ganglion cells of the 
Hippocampus major of Macacus rhesus (see Table IV) have confirmed 
us in our view that the so-called Chlamydozoa in rabies are nothing 
more nor less than a development round nucleolar fragments. The 
tissues were hardened in Zenker’s fluid, washed and passed through 
graduated alcohols, cleared, embedded in paraffin wax. The mercury 
