156 
THE SUCCESSFUL DRUG TREATMENT OF CANINE PIRO- 
PLASMOSIS, TOGETHER WITH OBSERVATIONS UPON 
THE EFFECT OF DRUGS ON PIROPLASMA GANIS. 
By GEORGE H. F. NUTTALL, M.D., Ph.D., Sc.D., F.R.S., 
Quick Professor of Biology, Cambridge, 
and S. HADWEN, D.V.Sc. (McGill), 
First Assistant Pathologist, Health of Animals Branch, Department 
of Agriculture, Canada. 
(1 Text Figure.) 
CONTENTS. 
PAGE 
Introduction ............ 156 
Experiments with Arsacetin and Soamin ...... 158 
The development of Piroplasma canis in untreated dogs . . . 160 
Method of enumerating the different forms of intraeorpuscular parasites . 161 
Enumeration of parasites in untreated dogs ...... 162 
Effects of Trypanblau and Trypanrot upon the morphology of P. canis . 163 
Enumeration of parasites in treated dogs ...... 166 
Records of Experiments relating to: 
Control Dogs.169 
Records of Dogs treated with Trypanrot.172 
Records of Dogs treated with Trypanblau.175 
Summary ............. 187 
Conclusions ............ 189 
References.191 
In a previous paper, Nuttall and Graham-Smith (x. 1908) reported 
upon various experiments they had conducted with a view to finding a 
remedy for Canine piroplasmosis. They found that Quinine bihydro¬ 
chloride, Tartar emetic, Sodium-methyl-arsenate, Methylene blue and 
Beta-naphthylamiue exerted no curative action upon the disease, and 
they cited experiments conducted by Gonder (1907) which showed 
