166 
The Cure of Piroplasmosis 
The enumeration of parasites in treated dogs. 
We have already stated that the chief effect of Trypanblau and 
Trypanrot is to cause the disappearance of the pyriforms and a relative 
increase in the percentage of rounded parasites. Accompanying the fall 
in the relative number of pyriform parasites there is also a fall in the 
percentage of infected as compared to uninfected corpuscles. That this 
is the case is best shown by the following enumerations taken from our 
protocols. 
For instance, in the case of Dog 2, prior to its being treated on the 
11th day after inoculation, for every 100 (0) parasites there were present 
the following numbers of (PP) parasites: 
Variation within 14 hours Variation within 13 hours Variation on 
on day 7 on day 8 days 9 10 11 
u / 0 of (PP) 122 83 140 74 82 58 104 78 42 54 50 44 
% of infected r.b.c. ? ? ? 0-1 ? 0-4 0-4 1-5 5 5-6 6-4 6 
The sign “?” indicates that there were too few parasites present to 
determine the percentage. 
This dog was treated with a small dose of Trypanrot on the 11th day, 
with the result that the number of (PP) parasites and the percentage of 
infection both fell as follows, all parasites having disappeared on the 
15th day: 
Day 11 12 13 14 15 
Intervals of 22J hours 24 hours 24 hours 24 hours 
°/ 0 of(PP) 44 T 30 13 9 0 
°/ 0 of infected r.b.c. 6 2-6 2-2 ? 0 
(“ T ” indicates when the drug was given.) 
The following extracts from the protocols of four other dogs show a 
. similar effect of a dose of Trypanblau, the order being according to the 
degree of infection of the corpuscles at the time when the drug was 
given: 
Record of Dog 10. 
Intervals of 34hrs. 2Jhrs. 2hrs. 2^hrs. 2-Jhrs. 2|hrs. 1 hr. GJhrs. 2|hrs. 
°/ 0 of(PP) 68 78 T 32 13 0-5 2 0-5 0 0-5 0 
°/o° f - fect ! 1-5 4-5 3-8 7* 3T 27 2 1-5 07 ? 
ed r.b.c. ) 
* This high °/ 0 was doubtless due to massage of the ear to promote blood flow 
after puncturing the earvein. 
