172 
The Cure of Piroplasmosis 
Records of treated dogs. 
Experiments with Trypanrot. 
We only carried out two experiments with Trypanrot. In the first 
experiment ( Dog 1) the drug was given on four occasions. This dog 
developed a very mild and chronic form of the disease, only appearing 
ill at the commencement. The dog appeared well and lively after 
the 16th day from the time of inoculation. No parasites were to be 
found in blood-films between the 15th and 28th days, after which 
they appeared irregularly in small numbers at the edge of the film 
only, as will be seen by reference to the protocol. The animal is 
still alive (111 days on 17. VI. 09), whereas the Control Dog II died 
on the 9th day after inoculation. This being one of our earlier ex¬ 
periments, the protocol does not include a detailed enumeration of 
infected corpuscles. 
In the second experiment ( Dog 2) the drug was given 6 days after 
the parasites appeared in the blood at a time when 6°/o of the corpuscles 
were infected. After 24 hours there were 2'6 % of infected corpuscles, 
and the dog had haemoglobinuria. No parasites could be subsequently 
detected, but nevertheless the dog died on the 20th day, apparently from 
the after-effects of the disease. The Control Dog VIII died on the 7th 
day after inoculation. 
Dog 1. 
Terrier, about 2 years old and of slight build, 
of drug. 
Day 
Weight 15 lbs. 
Beceived four doses 
(1. in. 09.) 1. 
5. 
6 . 
7. 
8 . 
9. 
10 . 
11 . 
12 . 
Inoculated with 5 o.c. of heart blood. 
A few parasites appeared in the blood. 
Treatment begun: 6 c.e. of 1 °/ 0 Trypanrot injected subcutaneously. 
15 infected r.b.c. per field, many (PP). 
Dog lively; 5 infected r.b.c. per field ; no (PP), only (0). 
Treatment: 6 c.c. of 1 °/ 0 Trypanrot as before. 
Dog not well; 10 infected r.b.c. per field, some (PP). 
Dog ill; 10 infected r.b.c. per field, some (PP). 
Treatment: 6 c.c. of 1 °/ 0 Trypanrot as before. Blood examined 
4 hours after administration of drug; only (O) parasites found in 
film. 
Dog fairly well, 1—2 infected r.b.c. per field; a few (PP). 
Dog better. Parasites hard to find. 
Dog much better; eats well. Infected r.b.c. very scarce, 5 (PP) found 
after much searching. 
