G . H. F. Nuttall and S. Hadwen 
187 
Dog 13. 
Mongrel Dane. 
Weight 30^ lbs. Deceived one dose of drug 24 hours after inoculation, 
. before the parasites could have appeared. 
Day Temp. °F. 
L hi. 09.) 1. 
— 
Inoculated with 5 c.c. of heart blood. 
2. 
— 
Treatment: 11 c.c. of sat. sol. Trypanblau. 
3. 
— 
Dog intensely blue. No local swelling from drug injection 
and no apparent after-effects from drag. 
4—24. 
Normal 
No parasites. 
25. 
9 9 
„ ,, Weight 34i lbs. (!) 
26—27. 
9 9 
9 9 99 
28. 
101-9. 
9 9 9 9 
30. 
101-3. 
9 9 9 9 
33. 
102-3. 
99 99 
36. 
102-4. 
9 9 9 9 
37. 
101-3. 
Blood not examined. 
39. 
102-4. 
No parasites. 
43. 
101-6. 
9 9 9 9 
!. v. 09.) 47. 
100-6. 
99 9 9 
49. 
101-6. 
99 9 9 
After this date the dog was examined for parasites up to the 65th day (29. v. 09) 
with negative result, and its temperature remained normal, except on the 
57th day when it ran to 103-4° F. On the 54th day the dog weighed 41| lbs. 
Note :—Dog not examined on days 29, 31, 32, 34, 35, 38, 40, 41, 42, 44, 45, 46, 48, etc. 
Control Dog VIII (see p. 171) died on the 7th day after inoculation. 
Summary. 
1. We have discovered that Trypanblau and Trypanrot are highly 
efficient remedies in the treatment of canine piroplasmosis, no drug or 
mode of treatment having hitherto been found to exert any appreciable 
effect upon this very fatal disease. 
2. The drugs exert a direct and observable effect upon the parasites 
(a) by causing the pyriform parasites to quickly disappear, and (b) in 
most cases, by causing the total disappearance of the parasites from 
microscopic observation in the peripheral blood. 
3. The disappearance of the parasites from the blood is usually 
temporary, the parasites reappearing in small numbers after an interval 
of 9 to 12 days, but the dogs, as a rule, show no symptoms and gradually 
progress toward recovery. In our experience there is but slight loss of 
weight in treated animals, this being in marked contrast to what is 
usually observed in dogs which recover naturally. In the two dogs 
which died of a relapse the parasites reappeared after an interval of 
4 to 5 days. 
