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The Cure of Piroplasmosis 
4. The experiments were conducted upon 21 dogs of all ages and 
of a variety of breeds. Many of the dogs were highly susceptible 
puppies. Twelve dogs were subjected to curative treatment, one 
dog received preventive treatment, and eight dogs served as controls. 
5. Twelve dogs received treatment as follows: 
(a) Two dogs were treated with Trypanrot and survived 111 days 
and 20 days respectively. In the latter case the dog was treated in an 
advanced stage of the disease, the parasites disappeared, and death 
appeared to be due to the after-effects of the malady. 
Two control dogs died respectively on the 9th and 7th day after 
they were inoculated. 
(b) Ten dogs were treated with Trypanblau and seven made a good 
recovery. Three of these dogs are still alive, having been respectively 
under observation for periods of 90, 88 and 65 days. Four of the 
recovered dogs died respectively of distemper on the 42nd and 43rd day, 
of severe mange on the 52nd day and of distemper and mange on the 
69th day 1 . We failed to cure the disease in 3 out of 10 cases treated: 
two small wormy ill-nourished puppies died from a relapse (on the 13th 
and 15th day) after they appeared to be on the road to recovery; one dog, 
treated only 3 hours prior to death, and when 50 °/o of its corpuscles were 
infected, succumbed to the disease, but even in this case a visible effect 
was exerted upon the parasites by the drug. 
Of the 7 control dogs, 6 died of piroplasmosis within 7—13 days 
after inoculation with virulent blood, and the remaining dog died of 
piroplasmosis on the 36th day after inoculation. 
6. After the parasites disappear under the influence of the drug, the 
temperature usually falls to normal, but slight rises of temperature may 
at times occur, together with the subsequent reappearance of the 
parasites. 
7. When the parasites reappear after treatment they occur in small 
numbers and can usually be detected only at the edge of the film. In 
such cases the parasites tend to occur in higher multiples [(PPPP) or 
more] within the individual corpuscles. The same appearance has 
been observed in one of the control dogs, which died of chronic 
piroplasmosis on the 36th day. 
8. In the two puppies 10 and 11, in which death followed upon a 
relapse, the parasites reappeared after a shorter interval (4 to 5 days) 
than in any of the other dogs. The blood counts made during the fatal 
1 It is worthy of note that distemper and mange, whilst greatly lowering the vitality 
of the dogs, do not influence the course of piroplasmosis and recovery from this disease. 
