G. H. F. Nuttall and S. Hadwen 
189 
relapse are remarkable as showing a high percentage of dividing forms 
(D); that rapid invasion of fresh corpuscles was proceeding is also shown 
by the high percentage of single pyriform parasites (P) which occurred 
in the corpuscles. 
9. One experiment is reported (Dog 13) in which Trypanblau was 
injected 24 hours after the animal was inoculated, with the result 
that no parasites appeared in the dog’s blood up to the 65th day, and 
the dog remained perfectly well. The control dog died of piroplasmosis 
on the 7th day. (This experiment has since been successfully repeated.) 
Further experiments of this character will be shortly reported upon. 
10. Arsacetin and Soamin exert no curative effect upon canine 
piroplasmosis. 
Conclusions. 
The obvious practical conclusion to be drawn from our results is 
that the remedies will prove of value in practice. There is a disad¬ 
vantage, which requires mention, in that the drugs, being dyes, cause a 
distinct colouration of the skin and mucous membranes of the animals 
which have been subjected to treatment. The colouration persists for 
some time. This aesthetic disadvantage is, however, outweighed by the 
fact that the drugs render it possible to save valuable animals for 
breeding or sporting purposes, or as pets in localities where dogs can 
scarcely be kept because of the prevalence of this deadly disease. 
The mere fact that a remedy has been found for a disease which has 
hitherto run its course, in spite of all treatment, is encouraging, since 
with time we may reasonably hope to secure a more perfect mode 
of treatment. The local effect at the seat of injection of the drug 
offers another disadvantage, but the effect is ti’ansitory and trivial when 
weighed in the balance as against saving the animal’s life. But for 
these effects the drug is well tolerated by dogs, for the treated animals 
appear lively and well. Where a cure is effected, the disease assumes, as 
we have seen, the chronic type which so frequently ends in complete re¬ 
covery and immunity for a period lasting, judging from observations in 
nature, usually for a year or more. 
The results of these experiments are of considerable scientific 
interest, since they throw additional light upon the biology of the 
parasites, and confirm the observations made by Nuttall and Graham- 
Smith upon the usual mode of multiplication of the parasites in the 
circulating blood. The striking effects of the drug in causing the dis¬ 
appearance of the pairs of pyriform parasites, so commonly found in 
infected corpuscles, led us directly to the enumeration of the different 
