248 
Drug Treatment of Redwater 
Observations on Treated Cattle. 
The beneficial effects of trypanblau treatment in cattle are not as 
striking as in dogs, because the disease in the cattle upon which we 
experimented was much less fatal than that in dogs. Nevertheless, 
the curative effect is quite evident when we observe the action of the 
drug upon the parasites and upon the symptoms of the disease and 
compare the data relating to the treated animals with those relating to 
the controls. 
If we accept the presence of Haemoglobinuria as an indication of 
the severity of the disease, it follows that the cases chosen for treatment 
chanced to be severer, taken as a whole, than the group of cases chosen 
to serve as controls. 
The Controls. Haemaglobinuria was observed in two out of the 
four Controls ; in Control Cow I it followed 24 hours after the appear¬ 
ance of parasites, lasted three days, and persisted until death ; in 
Control Cow IV haemoglobinuria followed 48 hours after the appear¬ 
ance of the parasites and persisted for five days. In both cases 
haemoglobinuria was severe. It is worthy of note that one of these 
two cows which had haemoglobinuria died from piroplasmosis. 
The treated animals. All of the five treated animals had haemo¬ 
globinuria, but recovered. In four the haemoglobinuria appeared on 
the day the animal was treated, but before the injection of the drug. 
In one cow (No. 1) haemoglobinuria was first noted 24 hours after 
treatment. The haemoglobinuria was severe in Cows 3 and 4, marked 
in Cows 1 and 5, slight in Cow 2. 
Haemoglobi nuria 
was noted in 
Cow 1 
5 5 
5 5 
55 
2 
3 
4 
5 
48 hours after the parasites appeared 
5 5 5 5 5 5 5 5 
22 
5 5 55 55 55 
when the parasites were first found 
49 hours after the parasites appeared 
Haemoglobinuria 
lasted 
24 hours. 
1 day. 
5 days. 
36 hours. 
48 „ 
To repeat: Whereas one of the two controls which had haemo¬ 
globinuria died of piroplasmosis, all of the five treated animals recovered, 
although they had haemoglobinuria. In the untreated cows haemo¬ 
globinuria lasted in one case three days when the animal died, in the 
other case five days when the animal recovered. In only one treated 
cow (3) did the haemoglobinuria last five days, in the others it lasted 
only 12, 24, 36 and 48 hours respectively. The differences in this 
respect are shown graphically in the charts (pp. 259 et seq.). 
