258 Drug Treatment of Redwater 
normal temperature of 102 = Fahr. is indicated by a double line in the 
chart. The rise and fall in the percentage of infected corpuscles is 
indicated below by vertical shading. Owing to the small number of 
parasites which was present in some cases the percentage of infection 
is not always drawn on the same scale in the different charts, but the 
shaded portion is drawn to scale for each chart, the maximum per¬ 
centage of infected r.b.c. being stated below. 
The variation in the relative percentages of the different types of 
parasites is given in accordance with the scale to the right of the chart. 
The percentage of rounded, ovoid or pyriform parasites (O) is the 
highest throughout and is indicated by a broken line. The percentages 
of double pyriform parasites (PP) and of dividing forms (D) are seen 
lower down on the chart. 
The haemoglobinuria is indicated by the horizontal shading above; 
its intensity is represented'by the amount of shaded area. Our method 
of determining the degree of haemoglobinuria was a rough one, but it 
sufficed for our purposes. It consisted in dipping strips of white filter 
paper into the samples of urine immediately after they were collected 
and allowing the strips to dry whilst suspended from a ledge. On each 
strip was noted the number of the cow and the time when the urine 
was collected. By spreading out the dried strips in a line the relative 
intensity of the colour of the paper was noted and the charts were 
shaded accordingly. 
The time when the animals (1 to 5) were treated is indicated by a 
vertical black line. When we compare the charts relating to Cow I 
and II (untreated) with the charts relating to the treated animals, it 
will be noticed (a) that the percentage of infected red blood corpuscles 
was greatest in the untreated animals; ( b) that the parasites persisted 
longer in the blood of the untreated animals (note the crosses above); 
(c) that the haemoglobinuria was not as intense in four out of the five 
treated cows as compared to the untreated animals; ( d ) that the 
percentage of infected corpuscles in the treated animals is seen to fall 
promptly after the injection of the drug; ( e ) that the dividing (D) and 
pyriform parasites (PP) disappear and are replaced by rounded, irregular 
and degenerating forms (O) which go to make up all the parasites 
which are left prior to the total disappearance of the piroplasmosis. 
