G. H. F. Nuttall and G. S. Graham-Smith 221 
African strain of P. cards. One dog was kept as a control and the other 
treated. One experiment was made with quinine bihydrochloride, two 
with tartar emetic, a drug which has been used with some success in 
trypanosome infections, two with sodium-methyl-arsenate (combined 
with calomel), and two with methylene blue, drugs which are reputed to 
be of value in the treatment of this disease. Two experiments were 
also made with Beta-naphthylamine. In no case however was the course 
or duration of the disease influenced in any way by the treatment. 
The records of our own experiments and of those of Gonder with 
atoxyl are given below. 
Quinine bihydrochloride. 
1. Dog I (puppy). 
Day 1. Inoculated with 3 c.c. of defibrinated heart blood. 
5. 2—3 infected corpuscles observed per field. 
Treatment begun : 2‘5 grains of quinine bihydrochloride dissolved in 
1 c.c. of normal salt solution injected subcutaneously twice a day. 
A 5 grain calomel pill also given daily. 
6. Treated as before, but the second dose of quinine raised to 5 grains. 
7. Found dead. 
Control dog (puppy) found dead on 6th day. 
Result. Treated dog died on 7th day, control dog on 6th day. 
Tartar emetic. 
2. Dog II (puppy). 
Day 1. Inoculated with 3 c.c. of defibrinated heart blood. 
3. Treatment begun before the appearance of the parasites. It consisted 
of daily subcutaneous injections of 20 minims (1T8 c.c.) of 0’25°/ 0 
tartar emetic. 
8. A few parasites observed in the blood. 
10. Many parasites in the blood. Haemoglobinuria. 
11. Found dead. 
Control dog (puppy) killed when dying on the 9th day. 
Result. Treated dog died on the 11th day, and control dog on the 9th day. 
3. Dog III (puppy). 
Day 1. Inoculated with 4 c.c. of defibrinated heart blood. 
6. Treatment begun : subcutaneous injections of 20 minims (1T8 c.c.) of 
a 0 - 5 °/ 0 solution of tartar emetic given daily. 
7. A few parasites observed in the blood. 
9. Many parasites in the blood. Haemoglobinuria. 
10. Found dead. 
Control dog (puppy) died on the 10th day showing many parasites in its blood. 
Residt. Treated and control dog both died on the 10th day. 
