222 
Treatment of Canine Piroplasmosis 
Sodium-methyl-arsenate. 
4. Dog IV (puppy). 
Day 1. Inoculated with 3 c.c. of defibrinated heart blood. 
5. 2—3 infected corpuscles observed per field. Treatment begun : 2 - 5 
grains of sodium-methyl-arsenate administered twice daily in a bread 
pill, together with a 5 grain calomel pill once daily. 
6. The afternoon dose of arsenate raised to 5 grains. 
7. 5 grains of arsenate given in the morning. 
Died at mid-day ; many parasites in the blood. 
Control dog (puppy) found dead on the 6th day. 
Result. Treated dog died on the 7th day and the control on the 6th day. 
5. Dog V (puppy). 
Day 1. Inoculated with 3 c.c. of defibrinated heart blood. 
8. A few parasites observed in the blood. Treatment begun : 5 grains of 
arsenate and a 5 grain calomel pill given once daily. 
9. Many parasites in the blood. Haemoglobinuria. 
10. Found dead. 
Control dog (puppy) showed many parasites on the 3rd day and died on the 
6th day. 
Result. Treated dog died on the 10th day, control dog on the 6th day. 
Methylene blue. 
6. Dog VI (puppy). 
Day 1. Inoculated with 3 c.c. of defibrinated heart blood. 
4. A few parasites observed in the blood. Treatment begun : 1 grain of 
methylene blue administered daily in the form of a pill. 
7. Many parasites in the blood. Dog died. 
Control dog (puppy) died on the 7th day with many parasites in its blood. 
Result. Treated and control dogs both died on the 7th day. 
7. Dog VII (puppy). 
Day 1. Inoculated with 2 c.c. of defibrinated heart blood. 
11. No parasites found up to this time. 
12. Again inoculated with 5 c.c. of defibrinated heart blood. 
19. No parasites found up to this time. 
20. Reinoculated with 6 c.c. of defibrinated heart blood. 
22. A few parasites observed in the blood. Treatment begun : 1 grain of 
methylene blue administered in the form of a pill daily. 
24. Found dead with many parasites in the blood. 
Result. No evidence that treatment had any effect. 
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