G. H. F. Nuttall and G. S. Graham-Smith 223 
Beta-naphthylamine. 
8. Dog VIII (puppy). 
Day 1. Inoculated with 8 c.c. of defibrinated heart blood. 
7. A few parasites found in the blood. 5 c.c. of a 3 % solution of Beta- 
naphthylamine given subcutaneously. 
8. Dog found dead. 
Control dog (puppy) died with numerous parasites in its blood on the 6th day. 
Result. Treated dog died 8th day and control dog on the 6th day. 
9. Dog IX (puppy). 
Day 1. Inoculated with 4 c.c. of defibrinated heart blood. 
4. Few parasites found in the blood. Received 5 c.c. of a 3 % solution of 
Beta-naphthylamine subcutaneously. 
5. Received 5 c.c. of 3 % solution of Beta-naphthylamine. 
6. Not treated. 
7. Found dead. 
Control dog (puppy) died with numerous parasites in its blood on the 5th day. 
Result. Treated dog died on the 7th day and the control dog on the 5th day. 
Atoxyl. 
In the experiments carried out by Gonder (1908, p. 301) the dogs 
were infected by means of intraperitoneal inoculations of blood contain¬ 
ing Piroplasma cams. Three dogs served as controls while six dogs 
received treatment. One of the control dogs was treated after parasites 
appeared in its blood (control to experiments Y and VI). We have 
not experimented with this drug but have condensed Gonder’s descrip¬ 
tions in such a manner as to make them easily comparable with our own 
observations. 
I. Dog “2” (l - 25 years old) treated with atoxyl before inoculation. The dog 
received subcutaneous injections of a 1 % solution of atoxyl every two days during 
two weeks, the dose being gradually raised from 5 c.c. to 10 c.c. (The total amount 
of the drug injected was not stated.) 
Day 1. Inoculated with 3 c.c. of blood. 
3. A few parasites found in the blood. 
4. Many parasites in the blood. Haemoglobinuria. The condition grew 
steadily worse and 
14. the dog died of piroplasmosis. 
II. Dog “ 3 ” (7 months old) treated with atoxyl before and after inoculation. 
It was treated in the same way as dog I receiving 3—5 c.c. of a 1 % solution of 
atoxyl on 6 days (45 c.c. of the solution in all). 
i 
