224 
Treatment of Canine Piroplasmosis 
Day 1. Inoculated with 3 c.e. of piroplasma blood. 
4. Parasites found in the blood. 
5. Died of heart failure, parasites found in the organs at autopsy. 
Control to experiments I and II : dog (2'5 months old) inoculated with 2'5 c.c. 
of piroplasma blood. A few parasites found in the blood on the 3rd day ; many on 
the 4th day, haemoglobinuria. Found dead on the 6th day. 
Result. The atoxyl treated dogs died on the 14th and 5th days respectively 
after inoculation, the control dog on the 6th day. 
III. Dog “6” (1‘5 years old) treated with atoxyl before and after treatment. 
It received subcutaneous injections of a 1 % solution of atoxyl every second day, 
the dose increasing gradually from 4 to 9 c.c. before the dog was inoculated. 
(79 c.c. of the drug were administered.) 
Day 1. Inoculated with 3 c.c. of piroplasma blood. 
3. Received 10 c.c. of atoxyl. 
4. Parasites observed. Haemoglobinuria. 
5. Many parasites in the blood. 12 c.c. of atoxyl given. 
7. Received 13 c.c. of atoxyl. 
9. „ 14 
11 . „ 12 
13. „ 9 
14. Dog died. Many parasites in the organs at autopsy. Jaundice. 
IV. Dog “ 5 ” (about 6 months old) treated with atoxyl from the time it was 
inoculated. 
Day 1. Inoculated with 3 c.c. of piroplasma blood. Received 4 c.c. of a 2 °/ 0 
solution of atoxyl. (Total amount given during illness 135 c.c.) 
3. Received 5 c.c. of atoxyl solution. 
4. A few parasites found. 
5. Many parasites in the blood. Haemoglobinuria. 4'5 c.c. of atoxyl 
given. 
6. Dog killed, had symptoms of rabies ; advanced piroplasmosis. 
Control to experiments III and IV; dog (about 2 years old) inoculated with 
3 c.c. of piroplasma blood. A few parasites appeared on the 3rd day and were 
found in the blood on the 10th day (intermittently). The dog recovered com¬ 
pletely. 
Result. Atoxyl treated dog, III, died on the 14th day, whilst dog IV was killed 
on the 6th day. The untreated conti’ol dog recovered completely. 
V. Dog “ 8 ” (2 years old) treated with atoxyl from the time it was inoculated. 
Day 1. Inoculated with 3 c.c. of piroplasma blood. Treatment: received 8 c.c. 
of a 1 % solution of atoxyl 3 hours before inoculation. 
3. Received 10 c.c. of a 1 % solution of atoxyl. Many parasites in the 
blood. Haemoglobinuria. 
6. Received 6 c.c. of a 2 % solution of atoxyl. 
8. Received 8 c.c. of a 2 % solution of atoxyl. (Total 22 c.c. of a 2 °/ 0 
solution.) 
Dog killed. Heavy infection. 
9. 
