J. D. E. Holmes 
291 
Treatment with atoxyl and arsenic. 
A four per cent, solution of atoxyl freshly prepared was used. The 
solution of arsenic was made according to the method of Loeffler and 
Ruehs as follows: 
Take 1 gramme arsenious acid, 10 c.c. normal soda solution. 
Dissolve by boiling. Add 10 c.c. normal hydrochloric acid and 
make up to 1000 c.c. 
Normal soda solution: 
42 grammes pure caustic soda. Dissolve in 800 c.c. aq. dist. When 
dissolved make up to 1000 c.c. 
Normal hydrochloric acid solution : 
Take 181 grammes (weight) hydrochloric acid @ IT sp. g. and 
make up to 1000 c.c. 
Mule C 33. 530 lbs., 2nd paroxysm. 
1st day 70 c.c. atoxyl. 
2nd ,, 500 c.c. ars. ac. sol. 
3rd ,, 1 gm. ars. ac. 
Six days interval. 
10th day 500 c.c ars. ac. sol. 
11 th ,, 00 c.c. atoxyl. 
No return of trypanosomes. 
Mule C 34. 550 lbs., 3rd paroxysm. 
1 st day 60 c.c. atoxyl. 
3rd ,, 500 c.c. ars. ac. sol. 
4th ,, 60 c.c. atoxyl. 
5th ,, 1 gm. ars. ac. 
Four days interval. 
10th day 500 c.c. ars. ac. sol. 
11 th ,, 60 c.c. atoxyl. 
12th ,, 1-5 gins. ars. ac. 
No return of trypanosomes. 
15th day of disease. 
12th day 1-5 gms. ars. ac. 
Four days interval. 
17th day 800 c.c. ars. ac. sol. 
18th ,, 60 c.c. atoxyl. 
19th ,, 2-5 gms. ars. ac. 
Kept under observation 5 months. 
25th day of disease. 
Four days interval. 
17th day 600 c.c. ars. ac. sol. 
18th ,, 60 c.c. atoxyl. 
19th ,, 2 gms. ars. ac. 
Eight days interval. 
28th day 600 c.c. ars. ac. sol. 
29th „ 60 c.c. atoxyl. 
30th ,, 2 gms. ars. ac. 
Kept under observation 5 months. 
Mule C 35. 500 lbs., 2nd paroxysm. 
1 st day 60 c.c. atoxyl. 
3rd ,, 600 c.c. ars. ac. sol. 
4th ,, 60 c.c. atoxyl. 
5th ,, 1-5 gms. ars. ac. 
Four days interval. 
10 th day 800 c.c. ars. ac. sol. 
11 th „ 60 c.c. atoxyl. 
12 th ,, 2 gms. ars. ac. 
No return of trypanosomes. 
15th day of disease. 
Four days interval. 
17th day 800 c.c. ars. ac. sol. 
18th ,, 50 c.c. atoxyl. 
19th ,, 2 gms. ars. ac. 
Eight days interval. 
28th day 800 c.c. ars. ac. sol. 
29th ,, 50 c.c. atoxyl. 
30th ,, 2 gms. ars. ac. 
Kept under observation 5 months. 
