J. D. E. Holmes 
293 
Mule B 1. 660 lbs., 3rd paroxysm. 25th day of disease. 
1 st day 600 c.e. ars. ac. sol. 
2 nd „ 60 c.e. atoxyl. 
3rd „ 1 gm. ars. ac. 
Four days interval. 
8 th day 500 c.c. ars. ac. sol. 
9th „ 50 c.c. atoxyl. 
10 th ,, 1 gm. ars. ac. 
Four days interval. 
15th day 600 c.c. ars. ac. sol. 
16th „ 70 c.c. atoxyl. 
17th ,, 1-5 gms. ars. ac. 
Eight days interval. 
26th day 800 c.c. ars. ac. sol. 
27th ,, 50 c.c. atoxyl. 
28th ,, 2 gms. ars. ac. 
Trypanosomes reappeared 17 days after treatment. In this case 
the doses were not sufficiently large. The amounts were not increased, 
as the animal showed symptoms of poisoning after the first series of 
doses. A second course of treatment with larger amounts would 
probably have succeeded. This was not tried owing to the number 
of other experiments in hand at the time. 
Mule B 2. 350 lbs., 3rd paroxysm. 25th 
1st day 50 c.c. atoxyl. 
3rd ,, 400 c.c. ars. ac. sol. 
4th ,, 50 c.c. atoxyl. 
5th ,, 1 gm. ars. ac. 
Eight days interval. 
14th day 400 c.c. ars. ac. sol. 
This mule showed symptoms 
that night. 
.ay of disease. 
15th day 50 c.c atoxyl. 
16th ,, 1 5 gms. ars. ac. 
Four days interval. 
21 st day 600 c.c. ars. ac. sol. 
22 nd ,, 60 c.c. atoxyl. 
23rd ,, 2 gms. ars. ac. 
of poisoning on the 25th day and died 
Pony C 40. 300 lbs., 3rd paroxysm. 
1st day 50 c.c. atoxyl. 
3rd ,, 400 c.c. ars. ac. sol. 
4th ,, 50 c.e. atoxyl. 
5th ,, 1 gm. ars. ac. 
Four days interval. 
10th day 400 c.c. ars. ac. sol. 
11th ,, 50 c.c. atoxyl. 
12 th ,, 1 gm. ars. ac. 
20 th day of disease. 
Four days interval. 
17th day 500 c.c. ars. ac. sol. 
18th ,, 60 c.c. atoxyl. 
19th ,, 1-5 gms. ars. ac. 
Four days interval. 
24th day 600 c.c. ars. ac. sol. 
25th ,, 60 c.c. atoxyl. 
26th ,, 1 gm. ars. ac. 
No return of trypanosomes. Kept under observation 5 months. 
Pony C 41. 400 lbs., 3rd paroxysm. 
1st day 500 c.c. ars. ac. sol. 
2nd ,, 50 c.c. atoxyl. 
3rd ,, 1 gm. ars. ac. 
Four days interval. 
8 th day 500 c.c. ars. ac. sol. 
9th ,, 50 c.c. atoxyl. 
No return of trypanosomes. 
20 th day of disease. 
10 th day 1 gm. ars. ac. 
Eight days interval. 
19th day 600 c.c. ars. ac. sol. 
20th ,, 50 c.c. atoxyl. 
21st ,, 1-5 gms. ars. ac. 
Kept under observation 5 months. 
Parasitology in 
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