J. D. E. Holmes 
295 
Mule B 5. 450 lbs., 2nd paroxysm. 18tli day of disease. 
1 st day 1 gm. ars. ac. 
3rd ,, 2 gms. „ 
6 th ,, 3 ,, , , 
This mule showed symptoms of poisoning and died on the 8th day. 
Pony C 45. 300 lbs., 2nd paroxysm. 
1 st day 1 gm. ars. ac. 
3rd ,, 1 „ 
5th ,, 1-5 gms. ,, 
8 th ,, 1*5 ,, ,, 
No return of trypanosomes. 
18th day of disease. 
10th day 1*25 gms. arc. ac. 
12 th „ 2 
14th „ 1*5 ,, ,, 
16th ,, 1*25 ,, ,, 
Kept under observation 5 months. 
Pony C 46. 350 lbs., 2nd paroxysm. 
1 st day 1 gm. ars. ac. 
3rd ,, 1 ,, ,, 
5th ,, 1 ,, ,, 
7th ,, 1*5 gms. „ 
9th „ 1*75 „ „ 
18th day of disease. 
11th day 1*75 gms. ars. arc. 
13th „ 1*75 ,, 
15th ,, 1*5 ,, ,, 
17th „ 1*75 ,, 
No return of trypanosomes. Kept under observation 5 months. 
Treatment with atoxyl and arsenious sulphide 
(chemically pure). 
Twelve ponies were treated with atoxyl and arsenious sulphide. 
The results were unsatisfactory. Ponies of 500 lbs. weight do not 
tolerate more than 10 gms. of the sulphide. In many cases a smaller 
dose proves fatal. Even in small amounts it is not borne so well as the 
arsenious acid. 
Out of the twelve ponies treated five wore discontinued at an early 
stage as each dose was followed by symptoms of poisoning. In six cases 
the treatment was pushed as far as possible, but relapses occurred a few 
weeks after the dosage was stopped. In one case the treatment was 
successful. 
Pony C 47. 350 lbs., 3rd paroxysm. 18th day of disease. 
1st day 50 e.c. atoxyl. 11th day 50 c.c. atoxyl. 
3rd ,, 6 gms. ars. sulph. 13th ,, 6 gms. ars. sulph. 
5th ,, 50 c.c. atoxyl. 15th ,, 50 c.c. atoxyl. 
9th „ 6 gms. ars. sulph. 
At this stage the pony showed symptoms of poisoning, and was in 
pain and off food for five days. No further treatment was given. 
No return of trypanosomes. Kept under observation 5 months. 
19—2 
