J. D. E. Holmes 
303 
The Atoxyl by itself has no curative effect, but exercises a rapid 
action in clearing the circulation of mature trypanosomes. It is, 
therefore, used only when trypanosomes are present in the circulation. 
The use is indicated at the commencement of treatment. If the first 
dose does not result in the complete disappearance of trypanosomes 
from the blood on the following day, a second injection of Atoxyl 
should be given 24 hours after the first dose. Atoxyl should be kept 
in the dark. The Atoxyl and Arsenic should be given after feeding. 
II. The injection of Atoxyl has to be followed by ten doses of 
Arsenious Acid in ball. Care must be taken in making up the balls 
and in mixing the drug with other ingredients. 
The doses which have been determined for horses according to their 
weight are detailed in the three attached tables. 
An interval of one day is allowed between each dose. 
The amount of Arsenious Acid is gradually increased. If after any 
dose the animal is dull or off feed, the next dose must be suspended 
till the symptoms have passed off. If after any doses the animal is off 
feed and uneasy and showing symptoms of colic, this shows that the 
animal cannot tolerate the amount of Arsenious Acid in that dose, and 
treatment must be suspended till the animal has recovered and the next 
lower dose used and no further increase in the following doses to be 
made. Animals showing symptoms of colic are to be treated with 
opium, chlorodyne or other sedative. 
Should trypanosomes reappear in the blood during treatment with 
Arsenic, Atoxyl should again be used to clear the circulation of the 
parasites after which the Arsenic is to be continued. 
III. Daily examination of the blood should be made and the 
result recorded with the daily temperature in the observation charts. 
After the completion of the, treatment the animal should be kept 
under observation, the blood being examined daily (or at least twice 
a week) for a period of two months. 
If a relapse occurs after the first course of treatment a second 
similar cour-se should be given with slightly increased doses of Arsenic. 
IV. Throughout the treatment the animal should receive a liberal 
diet and walking exercise. 
This treatment in our hands has given 75 per cent, of recoveries. 
V. If the animal is in a very advanced stage of Surra and in weak 
condition, it should be treated with Atoxyl injection alone at intervals 
of 3 to 4 days and receive care and full diet until it has sufficiently 
recovered to stand the doses of Arsenic. 
