INJECTION OF MEDICINES INTO THE VEINS. 
47 
spiration and circulation became ‘greatly accelerated and embar¬ 
rassed : the pulsations of the heart violent and distinctly audible 
on the left side; the submaxillary artery tense, pulse small; 
all the subcutaneous vessels distended; but as the plenitude 
of these vessels increased, the artery became more compressible ; 
the heart’s action less violent; the conjunctive and other mu¬ 
cous membranes pallid. Two hours after the injection, the 
animal grew dull, though his respiration continued short and 
accelerated; he cast looks at his flank, and was up and down 
like a horse with gripes. Urine abundant and very dark colour¬ 
ed. A small bleeding seemed to relieve him. The blood coagu¬ 
lated almost immediately; and was covered with a buffy coat 
which pervaded three-fourths of the mass. The symptoms gra¬ 
dually subsided, and eight hours afterwards the animal had per¬ 
fectly recovered.—28th. Ten pints were injected, which produc¬ 
ed similar but less marked derangement.—29th. Twelve pints 
were introduced, with same result.—30th. The injection was 
augmented to fifteen pints. The animal staggered and with 
difficulty walked into his stable. Here he lay down. Four 
hours afterwards however, after having staled copiously, he 
appeared quite well again. 
Similar results to these, which it is evident present nothing 
to alarm us, have attended the same experiment practised on 
several other horses, viz. Quickened respiration and circula¬ 
tion ; slight colics and vascular turgidity; —yielding to moderate 
bloodletting, copious urinary evacuations, and increased pul¬ 
monary exhalation. 
June 2. M. Dupuy injected twelve pints of warm water 
containing in solution grs.xij. of subcarbonate of ammonia. 
This seemed tp cause more and longer continued uneasiness, but 
not essentially to vary the symptoms.—6th. The same injection 
was repeated ; but more with a view of discovering what effect 
it might have on the disease (glanders) the mare had ; and it 
turned out that the swollen submaxillary glands, the nasal 
discharge, and the ulcerations of the membrane had disappeared 
in the course of the experiments.—10th. She was bled to death. 
Examinatio7i. Adhesions between the vaginal coverings of 
the testicles ; kidneys infiltrated with a reddish serum ; urinary 
canals enlarged ; mucous membrane of the stomach turned 
brown; lungs emphysematous, their inferior border present¬ 
ing incipient white hepatization, superior border tuberculous, 
besides many little cysts throughout their substance; incipient 
adhesions between the pericardial and costal pleurae; left 
lung marbled, brown and black (ecchymoses); interior of the 
